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MedKoo Cat#: 596999 | Name: Bicisate dihydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bicisate dihydrochloride, also known as ethyl cysteinate dimer (ECD), is usually complex with technetium Tc99m for its usage as a tracer to measure cerebral blood flow with single-photon emission computed tomography (SPECT). The complex of bicisate and technetium Tc99m as a kit was developed by Lantheus Medcl and FDA-approved on November 23, 1994.

Chemical Structure

Bicisate dihydrochloride
Bicisate dihydrochloride
CAS#14344-58-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 596999

Name: Bicisate dihydrochloride

CAS#: 14344-58-2 (HCl)

Chemical Formula: C12H26Cl2N2O4S2

Exact Mass:

Molecular Weight: 397.37

Elemental Analysis: C, 36.27; H, 6.60; Cl, 17.84; N, 7.05; O, 16.10; S, 16.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
121251-02-3 (free base) 14344-58-2 (HCl)
Synonym
Bicisate dihydrochloride; Bicisate HCl;
IUPAC/Chemical Name
diethyl 2,2'-(ethane-1,2-diylbis(azanediyl))(2R,2'R)-bis(3-mercaptopropanoate) dihydrochloride
InChi Key
HKASNZKRIQURIX-BZDVOYDHSA-N
InChi Code
InChI=1S/C12H24N2O4S2.2ClH/c1-3-17-11(15)9(7-19)13-5-6-14-10(8-20)12(16)18-4-2;;/h9-10,13-14,19-20H,3-8H2,1-2H3;2*1H/t9-,10-;;/m0../s1
SMILES Code
SC[C@@H](C(OCC)=O)NCCN[C@@H](CS)C(OCC)=O.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 397.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chao MY, Liu KT, Hsia YC, Liao MH, Shen LH. Direct determination of ECD in ECD Kit: a solid sample quantitation method for active pharmaceutical ingredient in drug product. J Biomed Biotechnol. 2011;2011:196238. doi: 10.1155/2011/196238. Epub 2011 Jun 9. PubMed PMID: 21687539; PubMed Central PMCID: PMC3114541. 2: Nobili F, Koulibaly PM, Rodriguez G, Benoit M, Girtler N, Robert PH, Brugnolo A, Darcourt J. 99mTc-HMPAO and 99mTc-ECD brain uptake correlates of verbal memory in Alzheimer's disease. Q J Nucl Med Mol Imaging. 2007 Dec;51(4):357-63. PubMed PMID: 17220817. 3: Koulibaly PM, Nobili F, Migneco O, Vitali P, Robert PH, Girtler N, Darcourt J, Rodriguez G. 99mTc-HMPAO and 99mTc-ECD perform differently in typically hypoperfused areas in Alzheimer's disease. Eur J Nucl Med Mol Imaging. 2003 Jul;30(7):1009-13. Epub 2003 May 15. PubMed PMID: 12750851. 4: Peremans K, Audenaert K, Blanckaert P, Jacobs F, Coopman F, Verschooten F, Van Bree H, Van Heeringen C, Mertens J, Slegers G, Dierckx R. Effects of aging on brain perfusion and serotonin-2A receptor binding in the normal canine brain measured with single photon emission tomography. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Dec;26(7-8):1393-404. PubMed PMID: 12502029. 5: Otte A, Ettlin T, Fierz L, Mueller-Brand J. Parieto-occipital hypoperfusion in late whiplash syndrome: first quantitative SPET study using technetium-99m bicisate (ECD). Eur J Nucl Med. 1996 Jan;23(1):72-4. PubMed PMID: 8586106. 6: Walovitch RC, Cheesman EH, Maheu LJ, Hall KM. Studies of the retention mechanism of the brain perfusion imaging agent 99mTc-bicisate (99mTc-ECD). J Cereb Blood Flow Metab. 1994 Jan;14 Suppl 1:S4-11. PubMed PMID: 8263070.