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MedKoo Cat#: 591502 | Name: Fluzinamide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fluzinamide has anticonvulsant action on amygdaloid seizures.

Chemical Structure

Fluzinamide
Fluzinamide
CAS# 76263-13-3

Theoretical Analysis

MedKoo Cat#: 591502

Name: Fluzinamide

CAS#: 76263-13-3

Chemical Formula: C12H13F3N2O2

Exact Mass: 274.0929

Molecular Weight: 274.24

Elemental Analysis: C, 52.56; H, 4.78; F, 20.78; N, 10.22; O, 11.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Fluzinamide; AHR 8559; AHR-8559; AHR8559
IUPAC/Chemical Name
1-Azetidinecarboxamide, N-methyl-3-(3-(trifluoromethyl)phenoxy)-
InChi Key
YULWJRNIKFFGNU-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H13F3N2O2/c1-16-11(18)17-6-10(7-17)19-9-4-2-3-8(5-9)12(13,14)15/h2-5,10H,6-7H2,1H3,(H,16,18)
SMILES Code
O=C(N1CC(OC2=CC=CC(C(F)(F)F)=C2)C1)NC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 274.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pledger GW, Laxer KD, Sahlroot JT, Taylor MR, Cereghino JJ, McCormick C, Whitley L, Manning LW. Pharmacokinetic and dose tolerability study of ADD 94057 in comedicated patients with partial seizures. Epilepsia. 1992 Jan-Feb;33(1):112-8. PubMed PMID: 1733743. 2: Johnson DN, Osman MA, Cheng LK, Swinyard EA. Pharmacodynamics and pharmacokinetics of AHR-11748, a new antiepileptic agent, in rodents. Epilepsy Res. 1990 Apr;5(3):185-91. PubMed PMID: 2384074. 3: Donofrio PD, Sackellares C, Madsen JA, Matsuo F, Abou-Khalil B, Berent S, Wagner J, Ater SB, Mavor H, Gay PE, et al. Pilot study of fluzinamide (N-methyl-3-[3-(trifluoromethyl)phenoxy]-1-azetidinecarboxamide) in refractory partial seizures. Neurology. 1985 Aug;35(8):1239-41. PubMed PMID: 4022365. 4: Osman MA, Pinchbeck FM, Cheng LK, Wright GJ. Simultaneous determination of fluzinamide and three of its active metabolites in plasma by high-performance liquid chromatography. J Chromatogr. 1984 Dec 12;336(2):329-36. PubMed PMID: 6530465. 5: Albertson TE, Joy RM, Stark LG. Anticonvulsant action of fluzinamide (AHR-8559) on kindled amygdaloid seizures. Epilepsia. 1984 Aug;25(4):511-7. PubMed PMID: 6745221.