IUPAC/Chemical Name
7-(((1R,2S,3E,5Z)-10-(4-acetyl-3-hydroxy-2-propylphenoxy)-1-hydroxy-1-(3-(trifluoromethyl)phenyl)deca-3,5-dien-2-yl)thio)-4-oxo-4H-chromene-2-carboxylic acid
InChi Key
IXJCHVMUTFCRBH-SDUHDBOFSA-N
InChi Code
InChI=1S/C38H37F3O8S/c1-3-11-29-31(18-17-27(23(2)42)36(29)45)48-19-9-7-5-4-6-8-14-34(35(44)24-12-10-13-25(20-24)38(39,40)41)50-26-15-16-28-30(43)22-33(37(46)47)49-32(28)21-26/h4,6,8,10,12-18,20-22,34-35,44-45H,3,5,7,9,11,19H2,1-2H3,(H,46,47)/b6-4-,14-8+/t34-,35+/m0/s1
SMILES Code
CCCc1c(O)c(ccc1OCCCC\C=C/C=C/[C@H](Sc2ccc3C(=O)C=C(Oc3c2)C(=O)O)[C@H](O)c4cccc(c4)C(F)(F)F)C(=O)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
710.76
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Colussi D, Parisot C, Lefèvre G. Binding of iralukast to serum proteins and erythrocytes: measurements using ultrafiltration and an erythrocyte partitioning method. Eur J Pharm Sci. 1999 Jan;7(2):167-73. doi: 10.1016/s0928-0987(98)00025-6. PMID: 9845802.
2. Capra V, Bolla M, Belloni PA, Mezzetti M, Folco GC, Nicosia S, Rovati GE. Pharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro. Br J Pharmacol. 1998 Feb;123(3):590-8. doi: 10.1038/sj.bjp.0701636. PMID: 9504401; PMCID: PMC1565194.
3. Capra V, Ravasi S, Bolla M, Viappiani S, Pagliardini S, Belloni PA, Mezzetti M, Folco GC, Nicosia S, Rovati GE. Evaluation of the pharmacological activity of the pure cysteinyl-leukotriene receptor antagonists CGP 45715A (iralukast) and CGP 57698 in human airways. Adv Exp Med Biol. 1999;469:313-8. doi: 10.1007/978-1-4615-4793-8_46. PMID: 10667347.
