Cloroperone hydrochloride is the salt form of Cloroperone (free base), a derivative of butyrophenone with anxiolytic properties. In animals, cloroperone causes slight CNS depression in mice, prevents the lethal effects of d-amphetamine under crowded conditions in mice, suppresses emesis in dogs. The drug was investigated in the clinic for the treatment of psychotic patients. It was shown to be effective anxiolytic at low dosages without sedation, listlessness, drowsiness or neurologic reactions. Cloroperone is a selective binder to 5-HT2 receptors (Ki 4.5 nM).
MedKoo Cat#: 591497
Name: Cloroperone HCl
CAS#: 55695-56-2 (HCl)
Chemical Formula: C22H24Cl2FNO2
Exact Mass: 423.1168
Molecular Weight: 424.34
Elemental Analysis: C, 62.27; H, 5.70; Cl, 16.71; F, 4.48; N, 3.30; O, 7.54
The following data is based on the product molecular weight 424.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
