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MedKoo Cat#: 596922 | Name: Tuna AI

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tuna AI is an angiotensin-converting enzyme (ACE) inhibitor. Tuna AI is a bioactive chemical isolaed from Tuna muscle.

Chemical Structure

Tuna AI
Tuna AI
CAS#117620-76-5

Theoretical Analysis

MedKoo Cat#: 596922

Name: Tuna AI

CAS#: 117620-76-5

Chemical Formula: C44H64N12O12

Exact Mass: 952.4767

Molecular Weight: 953.06

Elemental Analysis: C, 55.45; H, 6.77; N, 17.64; O, 20.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Tuna AI;
IUPAC/Chemical Name
L-prolyl-L-threonyl-L-histidyl-L-isoleucyl-L-lysyl-L-tryptophylglycyl-L-aspartic acid
InChi Key
QEULPEXEDWQVEI-DAZSAYDVSA-N
InChi Code
InChI=1S/C44H64N12O12/c1-4-23(2)36(55-41(64)32(17-26-20-46-22-50-26)54-43(66)37(24(3)57)56-39(62)29-13-9-15-47-29)42(65)52-30(12-7-8-14-45)40(63)53-31(16-25-19-48-28-11-6-5-10-27(25)28)38(61)49-21-34(58)51-33(44(67)68)18-35(59)60/h5-6,10-11,19-20,22-24,29-33,36-37,47-48,57H,4,7-9,12-18,21,45H2,1-3H3,(H,46,50)(H,49,61)(H,51,58)(H,52,65)(H,53,63)(H,54,66)(H,55,64)(H,56,62)(H,59,60)(H,67,68)/t23-,24+,29-,30-,31-,32-,33-,36-,37-/m0/s1
SMILES Code
O=C(O)C[C@@H](C(O)=O)NC(CNC([C@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CCCCN)NC([C@H]([C@@H](C)CC)NC([C@H](CC3=CNC=N3)NC([C@H]([C@H](O)C)NC([C@H]4NCCC4)=O)=O)=O)=O)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 953.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kohama Y, Kuroda T, Itoh S, Mimura T. Tuna muscle peptide, PTHIKWGD, inhibits leukocyte-mediated injury and leukocyte adhesion to cultured endothelial cells. Biol Pharm Bull. 1996 Jan;19(1):139-41. PubMed PMID: 8820927. 2: Kohama Y, Kuroda T, Iida K, Itoh S, Mimura T. Inhibitory effect of tuna peptide on endothelin production in cultured endothelial cells. Biol Pharm Bull. 1994 Jul;17(7):886-8. PubMed PMID: 8000369. 3: Kohama Y, Oka H, Murayama N, Iida K, Itoh M, Itoh M, Ying X, Mimura T. Increase of migration of cultured endothelial cells by angiotensin-converting enzyme inhibitor derived from tuna muscle. J Pharmacobiodyn. 1992 May;15(5):223-9. PubMed PMID: 1527698. 4: Kohama Y, Oka H, Matsumoto S, Nakagawa T, Miyamoto T, Mimura T, Nagase Y, Satake M, Takane T, Fujita T. Biological properties of angiotensin-converting enzyme inhibitor derived from tuna muscle. J Pharmacobiodyn. 1989 Sep;12(9):566-71. PubMed PMID: 2614645. 5: Kohama Y, Matsumoto S, Oka H, Teramoto T, Okabe M, Mimura T. Isolation of angiotensin-converting enzyme inhibitor from tuna muscle. Biochem Biophys Res Commun. 1988 Aug 30;155(1):332-7. PubMed PMID: 3415688.

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