Synonym
Thymotrinan; RGH 0205; RGH-0205; RG 0205; Thymotrinanum;
IUPAC/Chemical Name
L-arginyl-L-lysyl-L-aspartic acid
InChi Key
MJINRRBEMOLJAK-DCAQKATOSA-N
InChi Code
InChI=1S/C16H31N7O6/c17-6-2-1-5-10(14(27)23-11(15(28)29)8-12(24)25)22-13(26)9(18)4-3-7-21-16(19)20/h9-11H,1-8,17-18H2,(H,22,26)(H,23,27)(H,24,25)(H,28,29)(H4,19,20,21)/t9-,10-,11-/m0/s1
SMILES Code
O=C(O)C[C@@H](C(O)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)N)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
417.46
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Zhang Y, Feng J, Cui L, Zhang Y, Li W, Li C, Shi N, Chen Y, Kong W. Investigation Into Efficiency of a Novel Glycol Chitosan-Bestatin Conjugate to Protect Thymopoietin Oligopeptides From Enzymatic Degradation. J Pharm Sci. 2016 Feb;105(2):828-837. doi: 10.1002/jps.24567. Epub 2016 Jan 11. PubMed PMID: 26173563.
2: Schmidt MC, Rubas W, Merkle HP. Nasal epithelial permeation of thymotrinan (TP3) versus thymocartin (TP4): competitive metabolism and self-enhancement. Pharm Res. 2000 Feb;17(2):222-8. PubMed PMID: 10751039.
3: Heizmann J, Langguth P, Biber A, Oschmann R, Merkle HP, Wolffram S. Enzymatic cleavage of thymopoietin oligopeptides by pancreatic and intestinal brush-border enzymes. Peptides. 1996;17(7):1083-9. PubMed PMID: 8959740.
4: Görög S, Balogh G, Csehi A, Csizér E, Gazdag M, Halmos Z, Hegedüs B, Herényi B, Horváth P, Laukó A. Estimation of impurity profiles in drugs and related materials. Part 11--The role of chromatographic and spectroscopic methods in the estimation of side-reactions in drug syntheses. J Pharm Biomed Anal. 1993 Nov-Dec;11(11-12):1219-26. Review. PubMed PMID: 8123737.
5: Baló-Banga JM, Pintér E, Németh G. [Incidence of SLE in a patient thymectomized for myasthenia gravis]. Orv Hetil. 1993 Jun 20;134(25):1369-72. Hungarian. PubMed PMID: 8332357.
