Synonym
Cgp 52608; Cgp52608; Cgp-52608.
IUPAC/Chemical Name
Hydrazinecarbothioamide, N-methyl-2-(4-oxo-3-(2-propenyl)-2-thiazolidinylidene)-
InChi Key
DDYJDIHOSRTMSE-DHZHZOJOSA-N
InChi Code
InChI=1S/C8H12N4OS2/c1-3-4-12-6(13)5-15-8(12)11-10-7(14)9-2/h3H,1,4-5H2,2H3,(H2,9,10,14)/b11-8+
SMILES Code
N(\N=C1\SCC(N1CC=C)=O)C(NC)=S
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
244.34
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Winczyk K, Lawnicka H, Pawlikowski M, Kunert-Radek J, Karasek M. Growth-inhibitory action of melatonin and thiazolidinedione derivative CGP 52608 on murine 16/C breast cancer cells. Neuro Endocrinol Lett. 2006 Jun;27(3):351-4. PubMed PMID: 16816834.
2: Herrera F, Mayo JC, Martín V, Sainz RM, Antolin I, Rodriguez C. Cytotoxicity and oncostatic activity of the thiazolidinedione derivative CGP 52608 on central nervous system cancer cells. Cancer Lett. 2004 Jul 28;211(1):47-55. PubMed PMID: 15194216.
3: Winczyk K, Pawlikowski M, Karasek M. Melatonin and RZR/ROR receptor ligand CGP 52608 induce apoptosis in the murine colonic cancer. J Pineal Res. 2001 Sep;31(2):179-82. PubMed PMID: 11555175.
4: Karasek M, Pawlikowski M. Antiproliferative effects of melatonin and CGP 52608. Biol Signals Recept. 1999 Jan-Apr;8(1-2):75-8. PubMed PMID: 10085466.
5: Wiesenberg I, Chiesi M, Missbach M, Spanka C, Pignat W, Carlberg C. Specific activation of the nuclear receptors PPARgamma and RORA by the antidiabetic thiazolidinedione BRL 49653 and the antiarthritic thiazolidinedione derivative CGP 52608. Mol Pharmacol. 1998 Jun;53(6):1131-8. PubMed PMID: 9614218.
6: Tslm ST, Wong JT, Wong YH. CGP 52608-induced cyst formation in dinoflagellates: possible involvement of a nuclear receptor for melatonin. J Pineal Res. 1996 Sep;21(2):101-7. PubMed PMID: 8912235.
7: Wiesenberg I, Missbach M, Kahlen JP, Schräder M, Carlberg C. Transcriptional activation of the nuclear receptor RZR alpha by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand. Nucleic Acids Res. 1995 Feb 11;23(3):327-33. PubMed PMID: 7885826; PubMed Central PMCID: PMC306679.
