Mancozeb | CAS#8018-01-7 | fungicide

MedKoo Cat#: 558090 | Name: Mancozeb

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mancozeb is an agricultural ethylene bisdithiocarbamate fungicide.

Chemical Structure

Mancozeb

CAS#8018-01-7

Theoretical Analysis

MedKoo Cat#: 558090

Name: Mancozeb

CAS#: 8018-01-7

Chemical Formula: C8H12MnN4S8Zn

Exact Mass: 538.7500

Molecular Weight: 541.01

Elemental Analysis: C, 17.76; H, 2.24; Mn, 10.15; N, 10.36; S, 47.41; Zn, 12.08

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 400.00	2 Weeks

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Synonym

Acarie M; Agrox 16D; Blecar MN; Carmazine; Caswell No. 913A; CCRIS 2495;

IUPAC/Chemical Name

zinc;manganese(2+);N-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate

InChi Key

CHNQZRKUZPNOOH-UHFFFAOYSA-J

InChi Code

InChI=1S/2C4H8N2S4.Mn.Zn/c2*7-3(8)5-1-2-6-4(9)10;;/h2*1-2H2,(H2,5,7,8)(H2,6,9,10);;/q;;2*+2/p-4

SMILES Code

[S-]C(NCCNC([S-])=S)=S.[S-]C(NCCNC([S-])=S)=S.[Zn+2].[Mn+2]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

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Product Data

Product Data

Instruction

View handling instruction

Biological target:

Mancozeb is an ethylene-bis-dithiocarbamate fungicide.

In vitro activity:

To investigate the molecular mechanisms involved in male reprotoxicity induced by MZB (mancozeb), this study used primary cultures of mouse Sertoli-germ cells. Mancozeb reduced viability and increased the level of intracellular ROS, p38 and c-Jun N-terminal kinases (JNK) MAPK proteins phosphorylation, and apoptotic cell death, which could be blocked by NAC as an inhibitor of oxidative stress. The present study indicated for the first time the toxic manifestations of MZB on the Sertoli-germ cell co-culture. Reference: Toxicol Ind Health. 2021 Nov;37(11):674-684. https://pubmed.ncbi.nlm.nih.gov/34644184/

In vivo activity:

The present study investigated how L-carnitine affected the acoustic startle response (ASR) in rats exposed to mancozeb. The results showed that locomotor activity and the percentage of prepulse inhibition in the mancozeb groups decreased compared to the sham group while these parameters increased in the L-carnitine group (200 mg/kg) compared to sham rats. Reference: Toxicol Ind Health. 2023 Feb;39(2):115-126. https://pubmed.ncbi.nlm.nih.gov/36650049/

	Solvent	mg/mL	mM
Solubility
	DMSO	1.0	1.85
	Water	1.0	1.85

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 541.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Mohammadi-Sardoo M, Mandegary A, Nematollahi-Mahani SN, Moballegh Nasery M, Nabiuni M, Amirheidari B. Cytotoxicity of mancozeb on Sertoli-germ cell co-culture system: Role of MAPK signaling pathway. Toxicol Ind Health. 2021 Nov;37(11):674-684. doi: 10.1177/07482337211044028. Epub 2021 Oct 13. PMID: 34644184. 2. Dinisri I, Kodikara S, Prasadani M, Pathirana I, Rathnayake C, Alexander B, Lee KF, Kodithuwakku SP. Impairment of caprine oocyte maturation in vitro and alteration of granulosa cells functions by widely used fungicide mancozeb. Trop Anim Health Prod. 2021 Jul 21;53(3):406. doi: 10.1007/s11250-021-02854-5. PMID: 34287714. 3. Dehghani A, Pourjafari F, Koohkan F, Haghpanh T, Pourjafari F, Sheibani V, Afarinesh MR. L-carnitine attenuates acoustic startle reflex dysfunction in adult male rats exposed to mancozeb. Toxicol Ind Health. 2023 Feb;39(2):115-126. doi: 10.1177/07482337231151739. Epub 2023 Jan 17. PMID: 36650049. 4. Zhang Y, Bao J, Gong X, Shi W, Liu T, Wang X. Transcriptomics and metabolomics revealed the molecular mechanism of the toxic effect of mancozeb on liver of mice. Ecotoxicol Environ Saf. 2022 Sep 15;243:114003. doi: 10.1016/j.ecoenv.2022.114003. Epub 2022 Aug 22. PMID: 36007320.

In vitro protocol:

In vivo protocol:

1. Dehghani A, Pourjafari F, Koohkan F, Haghpanh T, Pourjafari F, Sheibani V, Afarinesh MR. L-carnitine attenuates acoustic startle reflex dysfunction in adult male rats exposed to mancozeb. Toxicol Ind Health. 2023 Feb;39(2):115-126. doi: 10.1177/07482337231151739. Epub 2023 Jan 17. PMID: 36650049. 2. Zhang Y, Bao J, Gong X, Shi W, Liu T, Wang X. Transcriptomics and metabolomics revealed the molecular mechanism of the toxic effect of mancozeb on liver of mice. Ecotoxicol Environ Saf. 2022 Sep 15;243:114003. doi: 10.1016/j.ecoenv.2022.114003. Epub 2022 Aug 22. PMID: 36007320.

1: Pavlovic V, Cekic S, Kamenov B, Ciric M, Krtinic D. The Effect of Ascorbic Acid on Mancozeb-Induced Toxicity in Rat Thymocytes. Folia Biol (Praha). 2015;61(3):116-23. PubMed PMID: 26213857. 2: Balaji B, Rajendar B, Ramanathan M. Quercetin protected isolated human erythrocytes against mancozeb-induced oxidative stress. Toxicol Ind Health. 2014 Jul;30(6):561-9. doi: 10.1177/0748233712462465. Epub 2012 Sep 28. PubMed PMID: 23024109. 3: Srivastava AK, Mishra S, Ali W, Shukla Y. Protective effects of lupeol against mancozeb-induced genotoxicity in cultured human lymphocytes. Phytomedicine. 2016 Jun 15;23(7):714-24. doi: 10.1016/j.phymed.2016.03.010. Epub 2016 Apr 11. PubMed PMID: 27235710. 4: Devi PA, Paramasivam M, Prakasam V. Degradation pattern and risk assessment of carbendazim and mancozeb in mango fruits. Environ Monit Assess. 2015 Jan;187(1):4142. doi: 10.1007/s10661-014-4142-6. Epub 2014 Nov 19. PubMed PMID: 25407993. 5: López-Fernández O, Yáñez R, Rial-Otero R, Simal-Gándara J. Kinetic modelling of mancozeb hydrolysis and photolysis to ethylenethiourea and other by-products in water. Water Res. 2016 Oct 1;102:561-571. doi: 10.1016/j.watres.2016.07.006. Epub 2016 Jul 8. PubMed PMID: 27423406. 6: Majumder S, Shakil NA, Kumar J, Banerjee T, Sinha P, Singh BB, Garg P. Eco-friendly PEG-based controlled release nano-formulations of Mancozeb: Synthesis and bioefficacy evaluation against phytopathogenic fungi Alternaria solani and Sclerotium rolfsii. J Environ Sci Health B. 2016 Dec;51(12):873-880. Epub 2016 Aug 12. PubMed PMID: 27715504. 7: Walia A, Mehta P, Guleria S, Chauhan A, Shirkot CK. Impact of fungicide mancozeb at different application rates on soil microbial populations, soil biological processes, and enzyme activities in soil. ScientificWorldJournal. 2014;2014:702909. doi: 10.1155/2014/702909. Epub 2014 Nov 16. PubMed PMID: 25478598; PubMed Central PMCID: PMC4248338. 8: Mandarapu R, Prakhya BM. In vitro myelotoxic effects of cypermethrin and mancozeb on human hematopoietic progenitor cells. J Immunotoxicol. 2015 Jan-Mar;12(1):48-55. doi: 10.3109/1547691X.2014.880535. Epub 2014 Feb 5. PubMed PMID: 24499300. 9: Hoffman L, Trombetta L, Hardej D. Ethylene bisdithiocarbamate pesticides Maneb and Mancozeb cause metal overload in human colon cells. Environ Toxicol Pharmacol. 2016 Jan;41:78-88. doi: 10.1016/j.etap.2015.11.002. Epub 2015 Nov 7. PubMed PMID: 26650801. 10: Yahia E, Aiche MA, Chouabbia A, Boulakoud MS. SUBCHRONIC MANCOZEB TREATEMENT INDUCED LIVER TOXICITY VIA OXIDATIVE STRESS IN MALE WISTAR RATS. Commun Agric Appl Biol Sci. 2014;79(3):553-9. PubMed PMID: 26080489. 11: Goldoni A, Klauck CR, Da Silva ST, Da Silva MD, Ardenghi PG, Da Silva LB. DNA damage in Wistar rats exposed to dithiocarbamate pesticide mancozeb. Folia Biol (Praha). 2014;60(4):202-4. PubMed PMID: 25152054. 12: Iorio R, Castellucci A, Rossi G, Cinque B, Cifone MG, Macchiarelli G, Cecconi S. Mancozeb affects mitochondrial activity, redox status and ATP production in mouse granulosa cells. Toxicol In Vitro. 2015 Dec 25;30(1 Pt B):438-45. doi: 10.1016/j.tiv.2015.09.018. Epub 2015 Sep 25. PubMed PMID: 26407525. 13: Atamaniuk TM, Kubrak OI, Husak VV, Storey KB, Lushchak VI. The Mancozeb-containing carbamate fungicide tattoo induces mild oxidative stress in goldfish brain, liver, and kidney. Environ Toxicol. 2014 Nov;29(11):1227-35. doi: 10.1002/tox.21853. Epub 2013 Feb 23. PubMed PMID: 23436297. 14: van Wendel de Joode B, Barbeau B, Bouchard MF, Mora AM, Skytt Å, Córdoba L, Quesada R, Lundh T, Lindh CH, Mergler D. Manganese concentrations in drinking water from villages near banana plantations with aerial mancozeb spraying in Costa Rica: Results from the Infants' Environmental Health Study (ISA). Environ Pollut. 2016 Aug;215:247-257. doi: 10.1016/j.envpol.2016.04.015. Epub 2016 May 19. PubMed PMID: 27208757. 15: Pandey SP, Mohanty B. The neonicotinoid pesticide imidacloprid and the dithiocarbamate fungicide mancozeb disrupt the pituitary-thyroid axis of a wildlife bird. Chemosphere. 2015 Mar;122:227-234. doi: 10.1016/j.chemosphere.2014.11.061. Epub 2014 Dec 12. PubMed PMID: 25496744. 16: Mirković B, Tanović B, Stević M, Hrustić J, Mihajlović M, Delibašić G, Vukša P. Toxicity of mancozeb, chlorothalonil, captan, fluopyram, boscalid, and difenoconazole to Didymella applanata isolates from Serbia. J Environ Sci Health B. 2015;50(12):845-50. doi: 10.1080/03601234.2015.1062648. Epub 2015 Aug 7. PubMed PMID: 26252498. 17: Harrison Brody A, Chou E, Gray JM, Pokyrwka NJ, Raley-Susman KM. Mancozeb-induced behavioral deficits precede structural neural degeneration. Neurotoxicology. 2013 Jan;34:74-81. doi: 10.1016/j.neuro.2012.10.007. Epub 2012 Oct 24. PubMed PMID: 23103283. 18: Cheng SY, Oh S, Velasco M, Ta C, Montalvo J, Calderone A. RTP801 regulates maneb- and mancozeb-induced cytotoxicity via NF-κB. J Biochem Mol Toxicol. 2014 Jul;28(7):302-11. doi: 10.1002/jbt.21566. Epub 2014 Apr 25. PubMed PMID: 24764117. 19: Pirozzi AV, Stellavato A, La Gatta A, Lamberti M, Schiraldi C. Mancozeb, a fungicide routinely used in agriculture, worsens nonalcoholic fatty liver disease in the human HepG2 cell model. Toxicol Lett. 2016 May 13;249:1-4. doi: 10.1016/j.toxlet.2016.03.004. Epub 2016 Mar 22. PubMed PMID: 27016407. 20: van Wendel de Joode B, Mora AM, Córdoba L, Cano JC, Quesada R, Faniband M, Wesseling C, Ruepert C, Oberg M, Eskenazi B, Mergler D, Lindh CH. Aerial application of mancozeb and urinary ethylene thiourea (ETU) concentrations among pregnant women in Costa Rica: the Infants' Environmental Health Study (ISA). Environ Health Perspect. 2014 Dec;122(12):1321-8. doi: 10.1289/ehp.1307679. Epub 2014 Sep 8. Erratum in: Environ Health Perspect. 2014 Dec;122(12):A321. PubMed PMID: 25198283; PubMed Central PMCID: PMC4256696.