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MedKoo Cat#: 596908 | Name: Argininosuccinate lithium
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Arginosuccinic acid is a basic amino acid, which is synthesized by some cells from citrulline, aspartic acid and used as a precursor for arginine in the urea cycle or Citrulline-NO cycle. The reaction is catalyzed by the enzyme argininosuccinate synthetase. Argininosuccinic acid (ASA) is the characteristic biomarker for the diagnosis of certain diseases. Note this product has ~80% purity with impurity ~20% water.

Chemical Structure

Argininosuccinate lithium
CAS#2230686-32-3 (dilithium)

Theoretical Analysis

MedKoo Cat#: 596908

Name: Argininosuccinate lithium

CAS#: 2230686-32-3 (dilithium)

Chemical Formula: C10H18N4O6.xLi (x=1~3, average=2)

Exact Mass: 290.1226

Molecular Weight: 302.14

Elemental Analysis: C, 39.75; H, 5.34; Li, 4.59; N, 18.54; O, 31.77 (x=1~3, average=2)

Price and Availability

Size Price Availability Quantity
10mg USD 550.00 2 Weeks
50mg USD 1,650.00 2 Weeks
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Related CAS #
2387-71-5 (free) 156637-58-0 (sodium) 918149-29-8 (disodium) 2230686-32-3 (dilithium)
Synonym
Argininosuccinic acid; L-Argininosuccinic acid lithium salt; Lithium L-argininosuccinate
IUPAC/Chemical Name
lithium (N-((S)-4-amino-4-carboxybutyl)carbamimidoyl)-L-aspartate
InChi Key
VCXQXPVAEFFUBO-USPAICOZSA-L
InChi Code
InChI=1S/C10H18N4O6.2Li/c11-5(8(17)18)2-1-3-13-10(12)14-6(9(19)20)4-7(15)16;;/h5-6H,1-4,11H2,(H,15,16)(H,17,18)(H,19,20)(H3,12,13,14);;/q;2*+1/p-2/t5-,6-;;/m0../s1
SMILES Code
O=C([O-])C[C@@H](C([O-])=O)NC(NCCC[C@H](N)C(O)=O)=N.[Li+].[Li+]
Appearance
Solid powder
Purity
>80% (or refer to the Certificate of Analysis), impurity (~20%) is water
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 302.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mamani-Huanca M, Gradillas A, López-Gonzálvez Á, Barbas C. Unraveling the Cyclization of l-Argininosuccinic Acid in Biological Samples: A Study via Mass Spectrometry and NMR Spectroscopy. Anal Chem. 2020 Oct 6;92(19):12891-12899. doi: 10.1021/acs.analchem.0c01420. Epub 2020 Sep 4. PMID: 32822159. 2: Seminotti B, da Silva JC, Ribeiro RT, Leipnitz G, Wajner M. Free Radical Scavengers Prevent Argininosuccinic Acid-Induced Oxidative Stress in the Brain of Developing Rats: a New Adjuvant Therapy for Argininosuccinate Lyase Deficiency? Mol Neurobiol. 2020 Feb;57(2):1233-1244. doi: 10.1007/s12035-019-01825-0. Epub 2019 Nov 9. PMID: 31707633. 3: Ganetzky RD, Bedoukian E, Deardorff MA, Ficicioglu C. Argininosuccinic Acid Lyase Deficiency Missed by Newborn Screen. JIMD Rep. 2017;34:43-47. doi: 10.1007/8904_2016_2. Epub 2016 Aug 12. PMID: 27515243; PMCID: PMC5509549. 4: Sass JO, Skladal D. Plasma concentrations and renal clearance of orotic acid in argininosuccinic acid synthetase deficiency. Pediatr Nephrol. 1999 Nov;13(9):912-6. doi: 10.1007/s004670050726. PMID: 10603147. 5: Aoyagi K, Akiyama K, Shahrzad S, Tomida C, Hirayama A, Nagase S, Takemura K, Koyama A, Ohba S, Narita M. Formation of guanidinosuccinic acid, a stable nitric oxide mimic, from argininosuccinic acid and nitric oxide-derived free radicals. Free Radic Res. 1999 Jul;31(1):59-65. doi: 10.1080/10715769900300601. PMID: 10489120. 6: Habbal ZM, Sakr A. Rapid, specific HPLC method for the determination of argininosuccinic acid following pre-column derivatization with o-phthaladehyde. Clin Chim Acta. 1997 Aug 29;264(2):239-43. doi: 10.1016/s0009-8981(97)00081-8. PMID: 9293382. 7: Fujimura Y, Kawamura M. A simple micro-method for determining urea cycle intermediates in blood: ornithine, arginine and argininosuccinic acid. Clin Chim Acta. 1996 Sep 30;253(1-2):1-8. doi: 10.1016/0009-8981(96)06340-1. PMID: 8879834. 8: Turner MA, Achyuthan AM, Hershfield MS, McInnes RR, Howell PL. Expression, purification, crystallization and preliminary X-ray analysis of human argininosuccinic acid lyase. J Mol Biol. 1994 Jun 3;239(2):336-8. doi: 10.1006/jmbi.1994.1372. PMID: 8196062. 9: Burns SP, Iles RA. An investigation of argininosuccinic acid anhydrides in argininosuccinic acid lyase deficiency by 1H-NMR spectroscopy. Clin Chim Acta. 1993 Nov 30;221(1-2):1-13. doi: 10.1016/0009-8981(93)90017-x. PMID: 8149628. 10: Widhalm K, Koch S, Scheibenreiter S, Knoll E, Colombo JP, Bachmann C, Thalhammer O. Long-term follow-up of 12 patients with the late-onset variant of argininosuccinic acid lyase deficiency: no impairment of intellectual and psychomotor development during therapy. Pediatrics. 1992 Jun;89(6 Pt 2):1182-4. PMID: 1594374. 11: Rand MJ, Li CG. Effects of argininosuccinic acid on nitric oxide-mediated relaxations in rat aorta and anococcygeus muscle. Clin Exp Pharmacol Physiol. 1992 May;19(5):331-4. doi: 10.1111/j.1440-1681.1992.tb00465.x. PMID: 1325882. 12: Gold ME, Wood KS, Buga GM, Byrns RE, Ignarro LJ. L-arginine causes whereas L-argininosuccinic acid inhibits endothelium-dependent vascular smooth muscle relaxation. Biochem Biophys Res Commun. 1989 Jun 15;161(2):536-43. doi: 10.1016/0006-291x(89)92632-6. PMID: 2500120. 13: Talbot HW, Sumlin AB, Naylor EW, Guthrie R. A neonatal screening test for argininosuccinic acid lyase deficiency and other urea cycle disorders. Pediatrics. 1982 Oct;70(4):526-31. PMID: 7122151. 14: González-Noriega A, Verduzco J, Prieto E, Velázquez A. Argininosuccinic acid synthetase deficiency in a hamster cell line and its complementation of argininosuccinic aciduria human fibroblasts. J Inherit Metab Dis. 1980;3(2):45-8. doi: 10.1007/BF02312521. PMID: 6777600. 15: Cartigny B, Dhondt JL, Farriaux JP. L'acide arginino-succinique, techniques d'étude biochimiques (à propos d'un cas d'arginino-succinyluria) [Argininosuccinic acid, technics of biochemical study (apropos of a case of argininosuccinyluria)]. Lille Med. 1975 Mar;20(3):169-79. French. PMID: 1160489. 16: Palmer T, Oberholzer VG, Levin B, Burgess EA. Urinary excretion of argininosuccinic acid. Clin Chim Acta. 1973 Sep 14;47(3):443-8. doi: 10.1016/0009-8981(73)90278-7. PMID: 4744836. 17: Lee CR, Pollitt RJ. New derivatives of argininosuccinic acid in the urine of a patient with argininosuccinicaciduria. Biochem J. 1972 Jan;126(1):79-87. doi: 10.1042/bj1260079. PMID: 5075233; PMCID: PMC1178353. 18: Lee CR, Pollitt RJ. The anhydrides of argininosuccinic acid. Tetrahedron. 1970 Jul;26(13):3113-21. doi: 10.1016/s0040-4020(01)92894-7. PMID: 5449035. 19: Kowalsky A, Ratner S. A nuclear magnetic resonance study of the anhydrides of argininosuccinic acid and related guanidino compounds. Biochemistry. 1969 Mar;8(3):899-907. doi: 10.1021/bi00831a020. PMID: 5781025. 20: Mäder AK, Rose HJ. Monilethrix und Argininbernsteinsäure-Ausscheidung [Monilethrix and excretion of argininosuccinic acid]. Dermatol Monatsschr. 1969;155(6):409-16. German. PMID: 5386751.