Synonym
Tetrahexyldecyl ascorbate; BV-OSC; Oristar THA; Nikkol BV-OSC; Ascorbyl Tetraisopalmitate; Vitamin C tetra-isopalmitate; Vitamin C-isopalmityl tetraester;
IUPAC/Chemical Name
(1S)-1-((2R)-3,4-bis((2-hexyldecanoyl)oxy)-5-oxo-2,5-dihydrofuran-2-yl)ethane-1,2-diyl bis(2-hexyldecanoate)
InChi Key
OEWBEINAQKIQLZ-CMRBMDBWSA-N
InChi Code
InChI=1S/C70H128O10/c1-9-17-25-33-37-45-50-58(49-41-29-21-13-5)66(71)76-57-62(77-67(72)59(51-42-30-22-14-6)54-46-38-34-26-18-10-2)63-64(79-68(73)60(52-43-31-23-15-7)55-47-39-35-27-19-11-3)65(70(75)78-63)80-69(74)61(53-44-32-24-16-8)56-48-40-36-28-20-12-4/h58-63H,9-57H2,1-8H3/t58?,59?,60?,61?,62-,63+/m0/s1
SMILES Code
CCCCCCCCC(C(OC[C@H](OC(C(CCCCCCCC)CCCCCC)=O)[C@@H]1C(OC(C(CCCCCCCC)CCCCCC)=O)=C(OC(C(CCCCCCCC)CCCCCC)=O)C(O1)=O)=O)CCCCCC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
1,129.78
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Min M, Egli C, Bartolome RA, Sivamani RK. Ex vivo Evaluation of a Liposome- Mediated Antioxidant Delivery System on Markers of Skin Photoaging and Skin Penetration. Clin Cosmet Investig Dermatol. 2024 Jun 21;17:1481-1494. doi: 10.2147/CCID.S461753. PMID: 38933604; PMCID: PMC11199168.
2: Min M, Pérez Damonte SH, Sivamani RK. Open-label topical application of tetrahexyldecyl ascorbate and acetyl zingerone containing serum improves the appearance of photoaging and uneven pigmentation. J Cosmet Dermatol. 2024 Aug;23(8):2628-2635. doi: 10.1111/jocd.16315. Epub 2024 Apr 17. PMID: 38634176.
3: Afzal N, Nguyen N, Min M, Egli C, Afzal S, Chaudhuri RK, Burney WA, Sivamani RK. Prospective randomized double-blind comparative study of topical acetyl zingerone with tetrahexyldecyl ascorbate versus tetrahexyldecyl ascorbate alone on facial photoaging. J Cosmet Dermatol. 2024 Jul;23(7):2467-2477. doi: 10.1111/jocd.16292. Epub 2024 Mar 25. PMID: 38525606.
4: Rajabi-Estarabadi A, Hartman CL, Iglesia S, Kononov T, Zahr AS. Effectiveness and tolerance of multicorrective topical treatment for infraorbital dark circles and puffiness. J Cosmet Dermatol. 2024 Feb;23(2):486-495. doi: 10.1111/jocd.16122. Epub 2023 Dec 19. PMID: 38112168.
5: Meyer TA, Swindell WR, Chaudhuri RK. Acetyl Zingerone: A Photostable Multifunctional Skincare Ingredient That Combats Features of Intrinsic and Extrinsic Skin Aging. Antioxidants (Basel). 2023 May 29;12(6):1168. doi: 10.3390/antiox12061168. PMID: 37371898; PMCID: PMC10295400.
6: Scheman A, Fournier E, Kerchinsky L. Allergic contact dermatitis to two eye creams containing tetrahexyldecyl ascorbate. Contact Dermatitis. 2022 Jun;86(6):556-557. doi: 10.1111/cod.14082. Epub 2022 Mar 8. PMID: 35194790.
7: Swindell WR, Randhawa M, Quijas G, Bojanowski K, Chaudhuri RK. Tetrahexyldecyl Ascorbate (THDC) Degrades Rapidly under Oxidative Stress but Can Be Stabilized by Acetyl Zingerone to Enhance Collagen Production and Antioxidant Effects. Int J Mol Sci. 2021 Aug 15;22(16):8756. doi: 10.3390/ijms22168756. PMID: 34445461; PMCID: PMC8395926.
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9: Herndon JH Jr, Jiang LI, Kononov T, Fox T. An Open Label Clinical Trial to Evaluate the Efficacy and Tolerance of a Retinol and Vitamin C Facial Regimen in Women With Mild-to-Moderate Hyperpigmentation and Photodamaged Facial Skin. J Drugs Dermatol. 2016 Apr;15(4):476-82. PMID: 27050703.
10: Herndon JH Jr, Jiang L, Kononov T, Fox T. An Open Label Clinical Trial of a Multi-Ingredient Anti-Aging Moisturizer Designed to Improve the Appearance of Facial Skin. J Drugs Dermatol. 2015 Jul;14(7):699-704. PMID: 26151786.
11: Makino ET, Mehta RC, Banga A, Jain P, Sigler ML, Sonti S. Evaluation of a hydroquinone-free skin brightening product using in vitro inhibition of melanogenesis and clinical reduction of ultraviolet-induced hyperpigmentation. J Drugs Dermatol. 2013 Mar;12(3):s16-20. PMID: 23545928.
12: Fitzpatrick RE, Rostan EF. Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage. Dermatol Surg. 2002 Mar;28(3):231-6. doi: 10.1046/j.1524-4725.2002.01129.x. PMID: 11896774.
