MedKoo Cat#: 561896 | Name: TES-1025
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TES-1025 is the first potent and selective inhibitor of human ACMSD (IC50 = 0.013 μM) that increases NAD+ levels in cellular systems. Defects in NAD+ homeostasis underpin a wide range of diseases, including cancer, metabolic disorders, and aging.

Chemical Structure

TES-1025
TES-1025
CAS# 1883602-21-8

Theoretical Analysis

MedKoo Cat#: 561896

Name: TES-1025

CAS#: 1883602-21-8

Chemical Formula: C18H13N3O3S2

Exact Mass: 383.0398

Molecular Weight: 383.44

Elemental Analysis: C, 56.38; H, 3.42; N, 10.96; O, 12.52; S, 16.72

Price and Availability

Size Price Availability Quantity
25mg USD 250.00 2 Weeks
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,350.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 3,850.00 2 Weeks
2g USD 6,450.00 2 Weeks
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Related CAS #
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Synonym
TES-1025; TES 1025; TES1025;
IUPAC/Chemical Name
3-[[[5-cyano-1,6-dihydro-6-oxo-4-(2-thienyl)-2-pyrimidinyl]thio]methyl]phenylacetic acid
InChi Key
RJQYGCGMQYVVIB-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H13N3O3S2/c19-9-13-16(14-5-2-6-25-14)20-18(21-17(13)24)26-10-12-4-1-3-11(7-12)8-15(22)23/h1-7H,8,10H2,(H,22,23)(H,20,21,24)
SMILES Code
O=C(O)CC1=CC=CC(CSC2=NC(C3=CC=CS3)=C(C#N)C(N2)=O)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 383.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cianci M, Giacchè N, Cialabrini L, Carotti A, Liscio P, Rosatelli E, De Franco F, Gasparrini M, Robertson J, Amici A, Raffaelli N, Pellicciari R. Structural Basis of Human Dimeric α-Amino-β-Carboxymuconate-ε-Semialdehyde Decarboxylase Inhibition With TES-1025. Front Mol Biosci. 2022 Apr 7;9:834700. doi: 10.3389/fmolb.2022.834700. PMID: 35463964; PMCID: PMC9021598. 2: Zhan T, Xiong H, Pang J, Zhang W, Ye Y, Liang Z, Huang X, He F, Jian B, He W, Gao Y, Min X, Zheng Y, Yang H. Modulation of NAD+ biosynthesis activates SIRT1 and resists cisplatin-induced ototoxicity. Toxicol Lett. 2021 Oct 1;349:115-123. doi: 10.1016/j.toxlet.2021.05.013. Epub 2021 Jun 4. PMID: 34089817. 3: Park KH, Kim SH. Adult zebrafish as an in vivo drug testing model for ethanol induced acute hepatic injury. Biomed Pharmacother. 2020 Dec;132:110836. doi: 10.1016/j.biopha.2020.110836. Epub 2020 Oct 6. PMID: 33035832; PMCID: PMC8189647. 4: Katsyuba E, Mottis A, Zietak M, De Franco F, van der Velpen V, Gariani K, Ryu D, Cialabrini L, Matilainen O, Liscio P, Giacchè N, Stokar-Regenscheit N, Legouis D, de Seigneux S, Ivanisevic J, Raffaelli N, Schoonjans K, Pellicciari R, Auwerx J. De novo NAD+ synthesis enhances mitochondrial function and improves health. Nature. 2018 Nov;563(7731):354-359. doi: 10.1038/s41586-018-0645-6. Epub 2018 Oct 24. PMID: 30356218; PMCID: PMC6448761. 5: Pellicciari R, Liscio P, Giacchè N, De Franco F, Carotti A, Robertson J, Cialabrini L, Katsyuba E, Raffaelli N, Auwerx J. α-Amino-β-carboxymuconate-ε- semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD+) Biosynthesis. J Med Chem. 2018 Feb 8;61(3):745-759. doi: 10.1021/acs.jmedchem.7b01254. Epub 2018 Jan 26. PMID: 29345930.