Lofepramine hydrochloride | CAS# 26786-32-3 | xxxxx

MedKoo Cat#: 581257 | Name: Lofepramine hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lofepramine is an antidepressant; serotonin and norepinephrine re-uptake inhibitor (SNRI). A psychotropic IMIPRAMINE derivative that acts as a tricyclic antidepressant and possesses few anticholinergic properties. It is metabolized to DESIPRAMINE. Lofepramine is a third generation tricyclic antidepressant utilized throughout Europe and Japan for the treatment of major depression.

Chemical Structure

Lofepramine hydrochloride

CAS#26786-32-3(HCl)

Theoretical Analysis

MedKoo Cat#: 581257

Name: Lofepramine hydrochloride

CAS#: 26786-32-3(HCl)

Chemical Formula: C26H28Cl2N2O

Exact Mass: 454.1579

Molecular Weight: 455.42

Elemental Analysis: C, 68.57; H, 6.20; Cl, 15.57; N, 6.15; O, 3.51

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Related CAS #

26786-32-3(HCl) 23047-25-8

Synonym

Lofepramine hydrochloride; DB-2182; WHR 2908A; WHR-2908A;

IUPAC/Chemical Name

4'-Chloro-2-((3-(10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)methylamino)acetophenone monohydrochloride

InChi Key

ZWZIQPOLMDPIQM-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H27ClN2O.ClH/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29;/h2-5,7-10,13-16H,6,11-12,17-19H2,1H3;1H

SMILES Code

O=C(C1=CC=C(Cl)C=C1)CN(CCCN2C3=CC=CC=C3CCC4=CC=CC=C42)C.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Lofepramine is an antidepressant; serotonin and norepinephrine re-uptake inhibitor (SNRI).

In vitro activity:

TBD

In vivo activity:

TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 455.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

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