Synonym
Aganodine; Aganodin
IUPAC/Chemical Name
Guanidine, (4,7-dichloro-2-isoindolinyl)-
InChi Key
DFKHOVYSCCPSHR-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H10Cl2N4/c10-7-1-2-8(11)6-4-15(3-5(6)7)14-9(12)13/h1-2H,3-4H2,(H4,12,13,14)
SMILES Code
NC(NN1CC2=C(C(Cl)=CC=C2Cl)C1)=N
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
245.12
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Molderings GJ, Bönisch H, Hammermann R, Göthert M, Brüss M. Noradrenaline release-inhibiting receptors on PC12 cells devoid of alpha(2(-)) and CB(1) receptors: similarities to presynaptic imidazoline and edg receptors. Neurochem Int. 2002 Feb;40(2):157-67. PubMed PMID: 11738482.
2: Sánchez-Blázquez P, Boronat MA, Olmos G, García-Sevilla JA, Garzón J. Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol. 2000 May;130(1):146-52. PubMed PMID: 10781010; PubMed Central PMCID: PMC1572044.
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7: Molderings GJ, Likungu J, Jakschik J, Göthert M. Presynaptic imidazoline receptors and non-adrenoceptor [3H]-idazoxan binding sites in human cardiovascular tissues. Br J Pharmacol. 1997 Sep;122(1):43-50. PubMed PMID: 9298527; PubMed Central PMCID: PMC1564902.
8: Alemany R, Olmos G, García-Sevilla JA. Labelling of I2B-imidazoline receptors by [3H]2-(2-benzofuranyl)-2-imidazoline (2-BFI) in rat brain and liver: characterization, regulation and relation to monoamine oxidase enzymes. Naunyn Schmiedebergs Arch Pharmacol. 1997 Jul;356(1):39-47. PubMed PMID: 9228188.
9: Schlicker E, Fink K, Kathmann M, Molderings GJ, Göthert M. Effects of imidazolines on noradrenaline release in brain: an investigation into their relationship to imidazoline, alpha 2 and H3 receptors. Neurochem Int. 1997 Jan;30(1):73-83. PubMed PMID: 9116590.
10: Fuder H, Schwarz P. Desensitization of inhibitory prejunctional alpha 2-adrenoceptors and putative imidazoline receptors on rabbit heart sympathetic nerves. Naunyn Schmiedebergs Arch Pharmacol. 1993 Aug;348(2):127-33. PubMed PMID: 7901772.
11: Molderings GJ, Moura D, Fink K, Bönisch H, Göthert M. Binding of [3H]clonidine to I1-imidazoline sites in bovine adrenal medullary membranes. Naunyn Schmiedebergs Arch Pharmacol. 1993 Jul;348(1):70-6. PubMed PMID: 8377842.
12: Fuder H, Selbach M. Characterization of sensory neurotransmission and its inhibition via alpha 2B-adrenoceptors and via non-alpha 2-receptors in rabbit iris. Naunyn Schmiedebergs Arch Pharmacol. 1993 Apr;347(4):394-401. PubMed PMID: 7685502.
13: Molderings GJ, Hentrich F, Göthert M. Pharmacological characterization of the imidazoline receptor which mediates inhibition of noradrenaline release in the rabbit pulmonary artery. Naunyn Schmiedebergs Arch Pharmacol. 1991 Dec;344(6):630-8. PubMed PMID: 1663588.
