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MedKoo Cat#: 130076 | Name: AG-690/11026014

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AG-690/11026014 is a PARP-1 inhibitor that has been shown to prevent Ang II-induced cardiomyocyte hypertrophy in mice and therefore, has potential to treat cardiac diseases.

Chemical Structure

AG-690/11026014
AG-690/11026014
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130076

Name: AG-690/11026014

CAS#: N/A

Chemical Formula: C17H19Cl2N5O4S

Exact Mass: 459.0535

Molecular Weight: 460.33

Elemental Analysis: C, 44.36; H, 4.16; Cl, 15.40; N, 15.21; O, 13.90; S, 6.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
AG-690/11026014; AG 690/11026014; AG690/11026014
IUPAC/Chemical Name
2-((7-(3-(4-Chlorophenoxy)propyl)-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)thio)acetamide hydrochloride
InChi Key
UDICOWCXHICWSU-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H18ClN5O4S.ClH/c1-22-14-13(15(25)21-16(22)26)23(17(20-14)28-9-12(19)24)7-2-8-27-11-5-3-10(18)4-6-11;/h3-6H,2,7-9H2,1H3,(H2,19,24)(H,21,25,26);1H
SMILES Code
O=C(N)CSC(N1CCCOC2=CC=C(Cl)C=C2)=NC(N(C)C(N3)=O)=C1C3=O.[H]Cl
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 460.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Liu M, Li Z, Chen GW, Li ZM, Wang LP, Ye JT, Luo HB, Liu PQ. AG-690/11026014, a novel PARP-1 inhibitor, protects cardiomyocytes from AngII-induced hypertrophy. Mol Cell Endocrinol. 2014 Jul 5;392(1-2):14-22. doi: 10.1016/j.mce.2014.05.010. Epub 2014 May 21. PMID: 24859603. 2. Feng GS, Zhu CG, Li ZM, Wang PX, Huang Y, Liu M, He P, Lou LL, Chen SR, Liu PQ. Synthesis of the novel PARP-1 inhibitor AG-690/11026014 and its protective effects on angiotensin II-induced mouse cardiac remodeling. Acta Pharmacol Sin. 2017 May;38(5):638-650. doi: 10.1038/aps.2016.159. Epub 2017 Feb 27. PMID: 28239158; PMCID: PMC5457692.