MedKoo Cat#: 591397 | Name: Prenylamine lactate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Prenylamine lactate, a drug formerly used in the treatment of angina pectoris but superseded by less hazardous drugs. Prenylamine depletes myocardial catecholamine stores and has some calcium channel blocking activity.

Chemical Structure

Prenylamine lactate
CAS#69-43-2

Theoretical Analysis

MedKoo Cat#: 591397

Name: Prenylamine lactate

CAS#: 69-43-2

Chemical Formula: C27H33NO3

Exact Mass: 419.2460

Molecular Weight: 419.57

Elemental Analysis: C, 77.29; H, 7.93; N, 3.34; O, 11.44

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Agozol; Angormin; Prenylamine lactate;
IUPAC/Chemical Name
Phenethylamine, N-(3,3-diphenylpropyl)-alpha-methyl-, lactate
InChi Key
QPOFIDVRLWJICD-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H27N.C3H6O3/c1-20(19-21-11-5-2-6-12-21)25-18-17-24(22-13-7-3-8-14-22)23-15-9-4-10-16-23;1-2(4)3(5)6/h2-16,20,24-25H,17-19H2,1H3;2,4H,1H3,(H,5,6)
SMILES Code
CC(NCCC(C1=CC=CC=C1)C2=CC=CC=C2)CC3=CC=CC=C3.OC(C)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 419.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Elizarov SM, Gavrilina AV, Danilenko VN. [Modulation of serine/threonine protein kinase activity in chloramphenicol-resistant mutants of Streptomyces avermitilis]. Mol Biol (Mosk). 2004 May-Jun;38(3):394-403. Russian. PubMed PMID: 15285607. 2: Pivovarov AS, Drozdova EI, Kotlyar BI. Calmodulin blockers decrease short-term plasticity of the cholinoreceptors of neurons of the edible snail. Neurosci Behav Physiol. 1991 Jul-Aug;21(4):289-95. PubMed PMID: 1721681. 3: Pivovarov AS, Drozdova EI, Kotliar BI. [Calmodulin blockaders weaken the short-term plasticity of the neuronal cholinoreceptors in the edible snail]. Zh Vyssh Nerv Deiat Im I P Pavlova. 1990 May-Jun;40(3):535-42. Russian. PubMed PMID: 2169160. 4: Fan JF, Matsuda R, Ishibashi M, Takeda Y. Determination of prenylamine lactate tablets by high performance liquid chromatography. Eisei Shikenjo Hokoku. 1988;(106):91-4. PubMed PMID: 3250662. 5: Issa AS, Mahrous MS, Salam MA, Soliman N. The use of 2,3-dichloro-5,6-dicyano-p-benzoquinone for the spectrophotometric determination of some cardiovascular drugs. Talanta. 1987 Jul;34(7):670-2. PubMed PMID: 18964385. 6: Onaya T, Takazawa K, Shibata K. The inhibitory effects of calmodulin antagonists on TSH-stimulated thyroid hormone release by mouse thyroid lobes. Endocrinol Jpn. 1987 Feb;34(1):89-95. PubMed PMID: 3038506. 7: Leary WP, Asmal AC, Williams P. Prenylamine lactate in the treatment of angina pectoris. Curr Ther Res Clin Exp. 1976 Feb;19(2):180-4. PubMed PMID: 813955. 8: Arora R. Prenylamine lactate in angina pectoris. Indian Heart J. 1973 Jan;25(1):62-6. PubMed PMID: 4197199. 9: Starey F. [The formation of collaterals in the coronary vascular system of the dog. Experimental proof of the collateral formation in the dog heart following prenylamine-lactate treatment]. Arzneimittelforschung. 1972 Aug;22(8):1317-20. German. PubMed PMID: 4678393. 10: Rosenbaum M, Lennon P, Horvath T. The haemodynamic effects of prenylamine lactate. Med J Aust. 1971 May 15;1(20):1053-6. PubMed PMID: 5556989. 11: Singh I, Khanna PK, Srivastava MC, Hoon RS. Extent of possible rehabilitation of service personnel with ischaemic heart disease. Br Heart J. 1970 Sep;32(5):665-70. PubMed PMID: 5470048; PubMed Central PMCID: PMC487389. 12: Wolyvovics M, Buti A, Folle LE, Dighiero J. [Effect of prenylamine lactate in angina pectoris]. Arq Bras Cardiol. 1970 Feb;23(1):7-16. Spanish. PubMed PMID: 5451900. 13: Cardoe N. Prenylamine lactate ('Synadrin') in patients with angina pectoris. Br J Clin Pract. 1968 Jul;22(7):299-301. PubMed PMID: 4873075. 14: Belle MS. Prenylamine lactate in the treatment of angina pectoris. J Fla Med Assoc. 1967 Feb;54(2):116-9. PubMed PMID: 6040838. 15: STEPHENSON P, DEWAR HA, NEWELL DJ. A clinical trial of prenylamine lactate (synadrin) in the treatment of angina of effort. Scott Med J. 1963 Jul;8:279-82. PubMed PMID: 13983903. 16: PHEAR DN. Ettriol trinitrate and prenylamine lactate in angina pectoris. Br Med J. 1963 Jun 15;1(5345):1608. PubMed PMID: 13943113; PubMed Central PMCID: PMC2124303. 17: KERRIDGE DF, MAZURKIE SJ, VEREL D. A clinical trial of prenylamine lactate--a long-lasting coronary dilator drug. Can Med Assoc J. 1961 Dec 16;85:1352-3. PubMed PMID: 14455345; PubMed Central PMCID: PMC1848641.