MedKoo Cat#: 562956 | Name: TSI-01
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TSI-01 is a selective inhibitor of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2 (LPCAT2).

Chemical Structure

TSI-01
TSI-01
CAS#704878-75-1

Theoretical Analysis

MedKoo Cat#: 562956

Name: TSI-01

CAS#: 704878-75-1

Chemical Formula: C14H11Cl2NO4

Exact Mass: 327.0065

Molecular Weight: 328.14

Elemental Analysis: C, 51.24; H, 3.38; Cl, 21.61; N, 4.27; O, 19.50

Price and Availability

Size Price Availability Quantity
5mg USD 500.00
10mg USD 800.00
25mg USD 1,250.00
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Related CAS #
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Synonym
TSI-01; TSI 01; TSI01;
IUPAC/Chemical Name
4-(3,4-Dichloro-2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-benzoic acid 1-methylethyl ester
InChi Key
LZAMLWVXUVJMPU-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H11Cl2NO4/c1-7(2)21-14(20)8-3-5-9(6-4-8)17-12(18)10(15)11(16)13(17)19/h3-7H,1-2H3
SMILES Code
O=C(OC(C)C)C1=CC=C(N2C(C(Cl)=C(Cl)C2=O)=O)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 328.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tarui M, Shindou H, Kumagai K, Morimoto R, Harayama T, Hashidate T, Kojima H, Okabe T, Nagano T, Nagase T, Shimizu T. Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2. J Lipid Res. 2014 Jul;55(7):1386-96. doi: 10.1194/jlr.M049205. Epub 2014 May 21. PubMed PMID: 24850807; PubMed Central PMCID: PMC4076079. Zhao T, Sun R, Ma X, Wei L, Hou Y, Song K, Jiang J. Overexpression of LPCAT1 enhances endometrial cancer stemness and metastasis by changing lipid components and activating the TGF/β-Smad2/3 signaling pathway. Acta Biochim Biophys Sin (Shanghai). 2022 Jun 25;54(7):904-916. doi: 10.3724/abbs.2022076. PMID: 35880567; PMCID: PMC9827807.