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MedKoo Cat#: 341109 | Name: Talampicillin hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Talampicillin hydrochloride is a biochemical.

Chemical Structure

Talampicillin hydrochloride
Talampicillin hydrochloride
CAS#39878-70-1

Theoretical Analysis

MedKoo Cat#: 341109

Name: Talampicillin hydrochloride

CAS#: 39878-70-1

Chemical Formula: C24H24ClN3O6S

Exact Mass: 517.1074

Molecular Weight: 517.98

Elemental Analysis: C, 55.65; H, 4.67; Cl, 6.84; N, 8.11; O, 18.53; S, 6.19

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Talampicillin hydrochloride; BRL 8988.
IUPAC/Chemical Name
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((aminophenylacetyl)amino)-3,3-dimethyl-7-oxo-, 1,3-dihydro-3-oxo-1-isobenzofuranyl ester, monohydrochloride, (2S-(2alpha,5alpha,6beta(S*)))-
InChi Key
PAZSYTCTHYSIAO-GVMCPMFUSA-N
InChi Code
InChI=1S/C24H23N3O6S.ClH/c1-24(2)17(22(31)33-23-14-11-7-6-10-13(14)21(30)32-23)27-19(29)16(20(27)34-24)26-18(28)15(25)12-8-4-3-5-9-12;/h3-11,15-17,20,23H,25H2,1-2H3,(H,26,28);1H/t15-,16-,17+,20-,23-;/m1./s1
SMILES Code
O1[C@@H](c2c(C1=O)cccc2)OC([C@H]1C(S[C@H]2N1C([C@H]2NC([C@H](N)c1ccccc1)=O)=O)(C)C)=O.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 517.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pawełczyk E, Płotkowiak Z, Helska M. Kinetics of talampicillin decomposition in solutions. Acta Pol Pharm. 2002 Jan-Feb;59(1):25-9. PubMed PMID: 12026108. 2: Pawełczyk E, Płotkowiak Z, Helska M. Kinetics of thermal decomposition of talampicillin hydrochloride in the solid state. Pharmazie. 2000 May;55(5):390-1. PubMed PMID: 11828623. 3: Yoshii T, Yoshikawa T, Furudoi S, Yoshioka A, Ohtsuka Y, Komori T. Evaluation of oral antimicrobial agent levels in tooth extraction sites. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Jun;91(6):643-8. PubMed PMID: 11402275. 4: Ensink JM, Vulto AG, van Miert AS, Tukker JJ, Winkel MB, Fluitman MA. Oral bioavailability and in vitro stability of pivampicillin, bacampicillin, talampicillin, and ampicillin in horses. Am J Vet Res. 1996 Jul;57(7):1021-4. PubMed PMID: 8807014. 5: Imayama S, Fukuda H, Hori Y. Drug eruptions following treatment with prodrugs: a review of the reported cases in Japan from 1984 to 1989. J Dermatol. 1991 May;18(5):277-80. Review. PubMed PMID: 1834713. 6: Nguyen NA, Mortada LM, Notari RE. Potential improvement in the shelf life of parenterals using the prodrug approach: bacampicillin and talampicillin hydrolysis kinetics and utilization time. Pharm Res. 1988 May;5(5):288-96. PubMed PMID: 3244638. 7: Akimoto Y, Nishimura H, Komiya M, Kaneko K, Fujii A, Tamura T. Ampicillin concentrations in human dental granuloma after a single oral administration of talampicillin. Antimicrob Agents Chemother. 1988 Apr;32(4):566-7. PubMed PMID: 3377465; PubMed Central PMCID: PMC172221. 8: Akimoto Y, Uda A, Omata H, Nishimura H, Komiya M, Kaneko K, Fujii A, Tamura T. Ampicillin concentrations in human serum and periodontal membrane following a single oral administration of talampicillin. Gen Pharmacol. 1988;19(4):515-6. PubMed PMID: 3410274. 9: Schönwald S, Beus I, Car V, Mahovlić V, Jeren T, Plavsić F, Brlić V. Bacampicillin, amoxycillin and talampicillin concentrations in bronchial secretions. Int J Clin Pharmacol Res. 1988;8(4):263-6. PubMed PMID: 3182115. 10: Yoshizawa M. [Influence of antibiotics on anti-inflammatory activity of anti-inflammatory drugs in simultaneous administration]. Nichidai Koko Kagaku. 1987 Mar;13(1):34-43. Japanese. PubMed PMID: 3506110. 11: Haginaka J, Wakai J. Liquid chromatographic determination of ampicillin and its metabolites in human urine by postcolumn alkaline degradation. J Pharm Pharmacol. 1987 Jan;39(1):5-8. PubMed PMID: 2880985. 12: Yamane N, Konnai T, Imoto T, Sekiguchi T, Tomita S, Ohta Y, Sasaki J. Blood levels and distribution of talampicillin and bacampicillin in NZW rabbits. Tokai J Exp Clin Med. 1986 May;11(2):91-9. PubMed PMID: 3564081. 13: Sjövall J, Huitfeldt B, Magni L, Nord CE. Effect of beta-lactam prodrugs on human intestinal microflora. Scand J Infect Dis Suppl. 1986;49:73-84. Review. PubMed PMID: 3547627. 14: Sasaki J, Gotoh J, Morihana K, Uematsu M, Takai H, Ohmura H, Abe H, Ikeshima K, Nishiyama K, Shiiki K, et al. [A comparative double blind study of lenampicillin and talampicillin in the treatment of oral infections]. Jpn J Antibiot. 1985 Sep;38(9):2453-80. Japanese. PubMed PMID: 3908737. 15: Fujita K, Sayama T, Abe S, Murayama T, Sugimoto M, Hara T. [The duration of antibacterial treatment following transurethral prostatectomy]. Jpn J Antibiot. 1985 Aug;38(8):2149-54. Japanese. PubMed PMID: 3852896. 16: Akimoto Y, Kaneko K, Fujii A, Tamura T. Ampicillin concentrations in human serum, gingiva, mandibular bone, dental follicle, and dental pulp following a single oral dose of talampicillin. J Oral Maxillofac Surg. 1985 Apr;43(4):270-6. PubMed PMID: 3856643. 17: Akimoto Y, Nishimura H, Komiya M, Shibata T, Kaneko K, Fujii A, Tamura T. Concentrations of ampicillin and cefadroxil in human serum and mixed saliva following a single oral administration of talampicillin and cefadroxil, and relationships between serum and mixed saliva concentrations. Gen Pharmacol. 1985;16(3):273-5. PubMed PMID: 4018542. 18: Benno Y, Mitsuoka T. Susceptibility of Bacteroides from swine abscesses to 13 antibiotics. Am J Vet Res. 1984 Dec;45(12):2631-3. PubMed PMID: 6524756. 19: Angelini NM, Ola FN. [In vitro hydrolysis of an ampicillin ester. I. Microbiologic evaluation]. Rev Latinoam Microbiol. 1983 Apr-Jun;25(2):109-12. Spanish. PubMed PMID: 6361948. 20: Mohanty KC, Roy RB. Treatment of uncomplicated gonorrhoea in women with talampicillin in a single oral 1.5 g dose. Br J Vener Dis. 1982 Jun;58(3):180-1. PubMed PMID: 7082979; PubMed Central PMCID: PMC1046040.