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MedKoo Cat#: 562944 | Name: Malonganenone A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Malonganenone A is a selective modulator of plasmodial Hsp70s with antimalarial activity.

Chemical Structure

Malonganenone A
Malonganenone A
CAS#882403-69-2

Theoretical Analysis

MedKoo Cat#: 562944

Name: Malonganenone A

CAS#: 882403-69-2

Chemical Formula: C26H38N4O2

Exact Mass: 438.2995

Molecular Weight: 438.61

Elemental Analysis: C, 71.20; H, 8.73; N, 12.77; O, 7.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Malonganenone A; Malonganenone-A; Malonganenone E; Malonganenone-E;
IUPAC/Chemical Name
3-Methyl-7-[(2E,6E,11Z)-3,7,11,15-tetramethyl-13-oxo-2,6,11-hexadecatrien-1-yl]-3,7-dihydro-6H-purin-6-one
InChi Key
YFUQCEYIDJYEII-HLMZKVHVSA-N
InChi Code
InChI=1S/C26H38N4O2/c1-19(2)15-23(31)16-22(5)12-8-10-20(3)9-7-11-21(4)13-14-30-18-27-25-24(30)26(32)28-17-29(25)6/h9,13,16-19H,7-8,10-12,14-15H2,1-6H3/b20-9+,21-13+,22-16-
SMILES Code
O=C1N=CN(C)C2=C1N(C/C=C(C)/CC/C=C(C)/CCC/C(C)=C\C(CC(C)C)=O)C=N2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 438.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cockburn IL, Boshoff A, Pesce ER, Blatch GL. Selective modulation of plasmodial Hsp70s by small molecules with antimalarial activity. Biol Chem. 2014 Nov 1;395(11):1353-62. doi: 10.1515/hsz-2014-0138. PubMed PMID: 24854538. 2: Clark PG, Lein M, Keyzers RA. Studies of the H-D exchange mechanism of malonganenone B. Org Biomol Chem. 2012 Mar 7;10(9):1725-9. doi: 10.1039/c2ob06926a. Epub 2012 Jan 16. PubMed PMID: 22246312. 3: Cockburn IL, Pesce ER, Pryzborski JM, Davies-Coleman MT, Clark PG, Keyzers RA, Stephens LL, Blatch GL. Screening for small molecule modulators of Hsp70 chaperone activity using protein aggregation suppression assays: inhibition of the plasmodial chaperone PfHsp70-1. Biol Chem. 2011 May;392(5):431-8. doi: 10.1515/BC.2011.040. Epub 2011 Mar 23. PubMed PMID: 21426241.