Synonym
AGN 191701; AGN-191701; AGN191701
IUPAC/Chemical Name
3-Thiophenecarboxylic acid, 5-(2-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)-1-propenyl)-, (E)-
InChi Key
ZEDKEKWGCXBKCJ-NTEUORMPSA-N
InChi Code
InChI=1S/C23H28O2S/c1-14(9-17-11-16(13-26-17)21(24)25)18-12-20-19(10-15(18)2)22(3,4)7-8-23(20,5)6/h9-13H,7-8H2,1-6H3,(H,24,25)/b14-9+
SMILES Code
O=C(C1=CSC(/C=C(C2=C(C)C=C3C(C)(C)CCC(C)(C)C3=C2)\C)=C1)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
368.54
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Standeven AM, Thacher SM, Yuan YD, Escobar M, Vuligonda V, Beard RL, Chandraratna RA. Retinoid X receptor agonist elevation of serum triglycerides in rats by potentiation of retinoic acid receptor agonist induction or by action as single agents. Biochem Pharmacol. 2001 Dec 1;62(11):1501-9. PubMed PMID: 11728386.
2: Elmazar MM, Rühl R, Nau H. Synergistic teratogenic effects induced by retinoids in mice by coadministration of a RARalpha- or RARgamma-selective agonist with a RXR-selective agonist. Toxicol Appl Pharmacol. 2001 Jan 1;170(1):2-9. PubMed PMID: 11141350.
3: Pakala R, Benedict CR. Modulation of endothelial cell proliferation by retinoid x receptor agonists. Eur J Pharmacol. 1999 Dec 3;385(2-3):255-61. PubMed PMID: 10607884.
4: Standeven AM, Escobar M, Beard RL, Yuan YD, Chandraratna RA. Mitogenic effect of retinoid X receptor agonists in rat liver. Biochem Pharmacol. 1997 Aug 15;54(4):517-24. PubMed PMID: 9313779.
5: Thacher SM, Standeven AM, Athanikar J, Kopper S, Castilleja O, Escobar M, Beard RL, Chandraratna RA. Receptor specificity of retinoid-induced epidermal hyperplasia: effect of RXR-selective agonists and correlation with topical irritation. J Pharmacol Exp Ther. 1997 Aug;282(2):528-34. PubMed PMID: 9262312.
6: Standeven AM, Beard RL, Johnson AT, Boehm MF, Escobar M, Heyman RA, Chandraratna RA. Retinoid-induced hypertriglyceridemia in rats is mediated by retinoic acid receptors. Fundam Appl Toxicol. 1996 Oct;33(2):264-71. PubMed PMID: 8921345.
