levacetylleucine | CAS#1188-21-2 | bioactive chemical

MedKoo Cat#: 596724 | Name: levacetylleucine

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

levacetylleucine, also known as L-Acetylleucine, is used for treating vestibular-related imbalance and vertigo.

Chemical Structure

levacetylleucine

CAS#1188-21-2 (free acid)

Theoretical Analysis

MedKoo Cat#: 596724

Name: levacetylleucine

CAS#: 1188-21-2 (free acid)

Chemical Formula: C8H15NO3

Exact Mass: 173.1052

Molecular Weight: 173.21

Elemental Analysis: C, 55.47; H, 8.73; N, 8.09; O, 27.71

Price and Availability

Size	Price	Availability	Quantity
5g	USD 250.00	2 Weeks
25g	USD 450.00	2 Weeks

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Related CAS #

1188-21-2 (free acid) 121-76-6 (monoethanolamine)

Synonym

L-Acetylleucine; Acetylleucine; NSC 206316; NSC-206316; NSC206316; levacetylleucinum; levacetylleucine

IUPAC/Chemical Name

acetyl-L-leucine

InChi Key

WXNXCEHXYPACJF-ZETCQYMHSA-N

InChi Code

InChI=1S/C8H15NO3/c1-5(2)4-7(8(11)12)9-6(3)10/h5,7H,4H2,1-3H3,(H,9,10)(H,11,12)/t7-/m0/s1

SMILES Code

CC(C)C[C@@H](C(O)=O)NC(C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

N-Acetyl-L-leucine is an endogenous metabolite.

In vitro activity:

TBD

In vivo activity:

This study demonstrates that orally administered N-acetyl-L-leucine (NALL) significantly improved motor and cognitive outcomes in the injured mice, led to the attenuation of cell death, and reduced the expression of neuroinflammatory markers after controlled cortical impact (CCI) induced experimental TBI in mice. Reference: Sci Rep. 2021 Apr 29;11(1):9249. https://pubmed.ncbi.nlm.nih.gov/33927281/

	Solvent	mg/mL	mM
Solubility
	DMSO	67.5	389.70
	Ethanol	35.0	202.06

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 173.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Hegdekar N, Lipinski MM, Sarkar C. N-Acetyl-L-leucine improves functional recovery and attenuates cortical cell death and neuroinflammation after traumatic brain injury in mice. Sci Rep. 2021 Apr 29;11(1):9249. doi: 10.1038/s41598-021-88693-8. PMID: 33927281; PMCID: PMC8084982. 2. Kaya E, Smith DA, Smith C, Morris L, Bremova-Ertl T, Cortina-Borja M, Fineran P, Morten KJ, Poulton J, Boland B, Spencer J, Strupp M, Platt FM. Acetyl-leucine slows disease progression in lysosomal storage disorders. Brain Commun. 2020 Dec 20;3(1):fcaa148. doi: 10.1093/braincomms/fcaa148. PMID: 33738443; PMCID: PMC7954382.

In vitro protocol:

TBD

In vivo protocol:

1: LEAU O, DUCROT R. [Action of acetylleucine on experimental vertigo in mice]. C R Seances Soc Biol Fil. 1957;151(7):1365-7. French. PubMed PMID: 13523909.