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MedKoo Cat#: 591374 | Name: Prazitone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Prazitone is a barbiturate derivative developed in the 1970s. Unlike most barbiturates, it has little or no sedative effects, instead acting as a non-sedating anxiolytic and antidepressant. Prazitone is discontinued.

Chemical Structure

Prazitone
CAS#2409-26-9

Theoretical Analysis

MedKoo Cat#: 591374

Name: Prazitone

CAS#: 2409-26-9

Chemical Formula: C16H19N3O3

Exact Mass: 301.1426

Molecular Weight: 301.35

Elemental Analysis: C, 63.77; H, 6.36; N, 13.94; O, 15.93

Price and Availability

This product was removed for the commercial reasons.
Related CAS #
No Data
Synonym
Prazitone; AGN 511; AGN-511; AGN511
IUPAC/Chemical Name
5-Phenyl-5-(2-piperidyl-methyl)barbituric acid
InChi Key
UGZAKKMLMJITLL-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H19N3O3/c20-13-16(11-6-2-1-3-7-11,14(21)19-15(22)18-13)10-12-8-4-5-9-17-12/h1-3,6-7,12,17H,4-5,8-10H2,(H2,18,19,20,21,22)
SMILES Code
O=C(NC(C1(C2=CC=CC=C2)CC3NCCCC3)=O)NC1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 301.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PubMed PMID: 27563872. 10: Park HB, Crawford JM. Pyrazinone protease inhibitor metabolites from Photorhabdus luminescens. J Antibiot (Tokyo). 2016 Aug;69(8):616-21. doi: 10.1038/ja.2016.79. Epub 2016 Jun 29. PubMed PMID: 27353165; PubMed Central PMCID: PMC5003743. 11: Belfrage AK, Abdurakhmanov E, Kerblom E, Brandt P, Oshalim A, Gising J, Skogh A, Neyts J, Danielson UH, Sandström A. Discovery of pyrazinone based compounds that potently inhibit the drug-resistant enzyme variant R155K of the hepatitis C virus NS3 protease. Bioorg Med Chem. 2016 Jun 15;24(12):2603-20. doi: 10.1016/j.bmc.2016.03.066. Epub 2016 Apr 8. PubMed PMID: 27160057. 12: Ahuja VT, Hartz RA, Molski TF, Mattson GK, Lentz KA, Grace JE Jr, Lodge NJ, Bronson JJ, Macor JE. Synthesis and evaluation of carbamate and aryl ether substituted pyrazinones as corticotropin releasing factor-1 (CRF₁) receptor antagonists. Bioorg Med Chem Lett. 2016 May 1;26(9):2184-7. doi: 10.1016/j.bmcl.2016.03.067. Epub 2016 Mar 17. 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