L 657925 | CAS#122757-59-9 | thromboxane A2 antagonist

MedKoo Cat#: 596608 | Name: L 657925

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L 657925 is a thromboxane A2 receptor antagonist.

Chemical Structure

L 657925

CAS#122757-59-9

Theoretical Analysis

MedKoo Cat#: 596608

Name: L 657925

CAS#: 122757-59-9

Chemical Formula: C21H21ClFNO2

Exact Mass: 373.1245

Molecular Weight: 373.85

Elemental Analysis: C, 67.47; H, 5.66; Cl, 9.48; F, 5.08; N, 3.75; O, 8.56

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

L657925; L 657925; L-657925;

IUPAC/Chemical Name

2-(9-(4-chlorobenzyl)-6-fluoro-2,3,4,4a,9,9a-hexahydro-1H-carbazol-1-yl)acetic acid

InChi Key

USFMJLOJQLMDAA-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H21ClFNO2/c22-15-6-4-13(5-7-15)12-24-19-9-8-16(23)11-18(19)17-3-1-2-14(21(17)24)10-20(25)26/h4-9,11,14,17,21H,1-3,10,12H2,(H,25,26)

SMILES Code

O=C(O)CC1C2N(CC3=CC=C(Cl)C=C3)C4=C(C=C(F)C=C4)C2CCC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 373.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Paul RV, Saxenhofer H, Wackym PS, Halushka PV. Stimulation of rat mesangial cell thromboxane A2 receptors inhibits particulate but not soluble guanylyl cyclase. Am J Physiol. 1996 Jan;270(1 Pt 2):F31-8. PubMed PMID: 8769820. 2: Zucker TP, Higashiura K, Mathur RS, Halushka PV. Androstenedione increases thromboxane A2 receptors in human erythroleukemia cells. Life Sci. 1996;58(8):683-90. PubMed PMID: 8594318. 3: Simmons TR, Cook JA, Moore JN, Halushka PV. Thromboxane A2 receptors in equine monocytes: identification of a new subclass of TXA2 receptors. J Leukoc Biol. 1993 Feb;53(2):173-8. PubMed PMID: 8383167. 4: Ueda N, Mayeux PR, Walker PD, Shah SV. Receptor-mediated increase in cytosolic calcium in LLC-PK1 cells by platelet activating factor and thromboxane A2. Kidney Int. 1991 Dec;40(6):1075-81. PubMed PMID: 1662319. 5: Mayeux PR, Morinelli TA, Williams TC, Hazard ES, Mais DE, Oatis JE, Baron DA, Halushka PV. Differential effect of pH on thromboxane A2/prostaglandin H2 receptor agonist and antagonist binding in human platelets. J Biol Chem. 1991 Jul 25;266(21):13752-8. PubMed PMID: 1830308.