L 644257 | CAS#68354-99-4 | synthetic glycolipid

MedKoo Cat#: 596574 | Name: L 644257

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L 644257 is a synthetic glycolipid for the study of in vivo behavior of liposomes.

Chemical Structure

L 644257

CAS#68354-99-4

Theoretical Analysis

MedKoo Cat#: 596574

Name: L 644257

CAS#: 68354-99-4

Chemical Formula: C39H69NO5S

Exact Mass: 663.4896

Molecular Weight: 664.04

Elemental Analysis: C, 70.54; H, 10.47; N, 2.11; O, 12.05; S, 4.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

L 644257; L-644257; L644257; 6-Coham; Nmanchol;

IUPAC/Chemical Name

(2R,3S,4S,5S,6R)-2-(aminomethyl)-6-((6-(((3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)hexyl)thio)tetrahydro-2H-pyran-3,4,5-triol

InChi Key

SQGBPXZJXZCRMK-LFMDNDDKSA-N

InChi Code

InChI=1S/C39H69NO5S/c1-25(2)11-10-12-26(3)30-15-16-31-29-14-13-27-23-28(17-19-38(27,4)32(29)18-20-39(30,31)5)44-21-8-6-7-9-22-46-37-36(43)35(42)34(41)33(24-40)45-37/h13,25-26,28-37,41-43H,6-12,14-24,40H2,1-5H3/t26-,28+,29+,30-,31+,32+,33-,34-,35+,36+,37-,38+,39-/m1/s1

SMILES Code

O[C@@H]([C@H]([C@@H]([C@@H](CN)O1)O)O)[C@H]1SCCCCCCO[C@H]2CC[C@]3(C)[C@@]4([H])CC[C@]5(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@]5([H])[C@]4([H])CC=C3C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 664.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ponpipom MM, Hagmann WK, O'Grady LA, Jackson JJ, Wood DD, Zweerink HJ. Glycolipids as host resistance stimulators. J Med Chem. 1990 Feb;33(2):861-7. PubMed PMID: 2299649. 2: Hagmann WK, Ponpipom MM, Jackson JJ, Wood DD, Boltz RC Jr, Zweerink HJ. Steroidal glycolipid, L-644,257, is a potent enhancer of nonspecific host resistance. Int J Immunopharmacol. 1990;12(2):241-6. PubMed PMID: 2329016. 3: Schwendener RA, Lagocki PA, Rahman YE. The effects of charge and size on the interaction of unilamellar liposomes with macrophages. Biochim Biophys Acta. 1984 Apr 25;772(1):93-101. PubMed PMID: 6712952. 4: Wu MS, Robbins JC, Bugianesi RL, Ponpipom MM, Shen TY. Modified in vivo behavior of liposomes containing synthetic glycolipids. Biochim Biophys Acta. 1981 Apr 17;674(1):19-29. PubMed PMID: 7236728.