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MedKoo Cat#: 596554 | Name: Diftalone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diftalone is an anti-Inflammatory drug.

Chemical Structure

Diftalone
CAS#21626-89-1

Theoretical Analysis

MedKoo Cat#: 596554

Name: Diftalone

CAS#: 21626-89-1

Chemical Formula: C16H12N2O2

Exact Mass: 264.0899

Molecular Weight: 264.28

Elemental Analysis: C, 72.72; H, 4.58; N, 10.60; O, 12.11

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Diftalone; Aladione; CCRIS 5458; L 5418; L-5418; L5418;
IUPAC/Chemical Name
phthalazino[2,3-b]phthalazine-5,12(7H,14H)-dione
InChi Key
CXSJGNHRBWJXEA-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H12N2O2/c19-15-13-7-3-1-5-11(13)9-17-16(20)14-8-4-2-6-12(14)10-18(15)17/h1-8H,9-10H2
SMILES Code
O=C(N(CC1=C2C=CC=C1)N3C2=O)C4=C(C3)C=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 264.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nabid MR, Rezaei SJ, Ghahremanzadeh R, Bazgir A. Ultrasound-assisted one-pot, three-component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones. Ultrason Sonochem. 2010 Jan;17(1):159-61. doi: 10.1016/j.ultsonch.2009.06.012. Epub 2009 Jun 18. PubMed PMID: 19589715. 2: Della Porta G, Dragani TA, Barale R, Zucconi D. Carcinogenic activity in mice of diftalone, an anti-inflammatory agent. J Cancer Res Clin Oncol. 1984;108(3):308-11. PubMed PMID: 6392305. 3: Welling PG, Tse FL. Food interactions affecting the absorption of analgesic and anti-inflammatory agents. Drug Nutr Interact. 1983;2(3):153-68. Review. PubMed PMID: 6381014. 4: Smith RJ. Nonsteroid anti-inflammatory agents: regulators of the phagocytic secretion of lysosomal enzymes from guinea-pig neutrophils. J Pharmacol Exp Ther. 1978 Nov;207(2):618-29. PubMed PMID: 712644. 5: Garnham JC, Saunders L, Stainton-Ellis DM, Franklin C, Volans G, Turner P, Natunen T. The effect of repeated administration of diftalone on enzyme induction. J Pharm Pharmacol. 1978 Jul;30(7):407-9. PubMed PMID: 27604. 6: Ambanelli U, Manganelli P, Nervetti A, Ugolotti G, Vaona GL. [Limitations of the isotopic evaluation of the effects of diftalone and indomethacin on inflammation induced with subcutaneous injection of microcrystals of monosodic urate]. Farmaco Prat. 1978 May;33(5):217-23. Italian. PubMed PMID: 369882. 7: Ambanelli U, Manganelli P, Nervetti A, Vaona GL. [Verification of the effect of diftalone on the inflammation caused by subcutaneous injection of microcrystalline monosodium urate]. Farmaco Prat. 1978;33(4):175-82. Italian. PubMed PMID: 153238. 8: Tenconi LT, Buniva G, Beretta E, Pagani V. Influence of food intake on the absorption of diftalone in man. Int J Clin Pharmacol Biopharm. 1977 Oct;15(10):485-91. PubMed PMID: 924704. 9: Buniva G, Sassella D, Beretta E. Plasma levels and urinary elimination of diftalone, paracetamol, and their metabolites after single oral administration in man. Int J Clin Pharmacol Biopharm. 1977 Oct;15(10):460-7. PubMed PMID: 924700. 10: Beretta E, Cristina T, Morrone A, Ratti B. Thin layer chromatography in the study of kinetics and metabolism of diftalone. Farmaco Prat. 1977 Oct;32(10):492-502. PubMed PMID: 556526. 11: Buniva G, Dubini A, Nicolis FG. Methodology of kinetic interaction studies in clinical pharmacology: an experimental contribution on diftalone and acetylsalicylic acid. Int J Clin Pharmacol Biopharm. 1977 Sep;15(9):438-43. PubMed PMID: 914407. 12: Zerilli LF, Assandri A. Isolation and characterization of 7-hydroxydiftalone beta-glucuronide. Farmaco Sci. 1977 Aug;32(8):549-59. PubMed PMID: 891909. 13: Tenconi LT, Beretta E, Cristina T, Morrone A. Plasma levels of diftalone in eight animal species evaluated by a TLC-spectrophotometric assay method. Farmaco Prat. 1977 Jun;32(6):284-90. PubMed PMID: 406144. 14: Dolecek R. Aladione (diftalone) in the treatment of subacute thyroiditis. J Int Med Res. 1977;5(5):346-53. PubMed PMID: 913862. 15: Magliulo E, Cipelli Benzi R, Luvarà A, Lago A. [Experimental studies of the effect of diftalone on the chemotaxis of human leukocytes in vitro]. Riv Emoter Immunoematol. 1977;24(1-2):53-60. Italian. PubMed PMID: 905722. 16: Bremová A, Pĕgrímová E, Rejholec V, Susta A, Truhlár P, Vykydal M. Double blind, multicenter study of diftalone and indomethacin in rheumatoid arthritis. Scand J Rheumatol Suppl. 1977;17:1-9. PubMed PMID: 897584. 17: Cucinotta D, Luvará A, Passeri M. Some laboratory aspects of hepatic tolerability of diftalone. Arzneimittelforschung. 1977;27(3):668-70. PubMed PMID: 577443. 18: Benedetti MS, Assandri A, Schelling JL, Villani F. Physiological disposition and plasma metabolites of a new anti-inflammatory agent, diftalone, in rat, dog, monkey and man. Arzneimittelforschung. 1977;27(12):2364-8. PubMed PMID: 414763. 19: Pasargiklian M, Bianco S, Allegra L, Moavero NE, Petrigni G, Robuschi M, Grugni A. Aspects of bronchial reactivity to prostaglandins and aspirin in asthmatic patients. Respiration. 1977;34(2):78-91. PubMed PMID: 407642. 20: Chalem F, Farias P, Lizarazo H, Peña P. Diftalone: a new non-steroidal anti-inflammatory agent: comparative study with phenylbutazone in the treatment of rheumatoid arthritis. J Int Med Res. 1977;5(1):18-25. PubMed PMID: 320061.