L 364918 | CAS#122211-31-8 | oxytocin antagonist

MedKoo Cat#: 596531 | Name: L 364918

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L 364918 is an oxytocin antagonist; synthetic derivative of L 156373.

Chemical Structure

L 364918

CAS#122211-31-8

Theoretical Analysis

MedKoo Cat#: 596531

Name: L 364918

CAS#: 122211-31-8

Chemical Formula: C40H54N8O6

Exact Mass: 742.4166

Molecular Weight: 742.92

Elemental Analysis: C, 64.67; H, 7.33; N, 15.08; O, 12.92

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

L 364918; L-364918; L364918; L 364,918; L-364,918; L364,918;

IUPAC/Chemical Name

(2S)-N-(L-alloisoleucyl)-N-((R)-1-cyclohexyl-3-oxopropan-2-yl)-1-((2R)-3-(3,3-di(pyridazine-3-carbonyl)cyclohexyl)-2-(methylamino)propanoyl)-2,3-dihydro-1H-pyrrole-2-carboxamide

InChi Key

RDHWFPFSGVZZKM-URWURDDHSA-N

InChi Code

InChI=1S/C40H54N8O6/c1-4-26(2)34(41)39(54)48(29(25-49)22-27-12-6-5-7-13-27)38(53)33-17-11-21-47(33)37(52)32(42-3)23-28-14-8-18-40(24-28,35(50)30-15-9-19-43-45-30)36(51)31-16-10-20-44-46-31/h9-11,15-16,19-21,25-29,32-34,42H,4-8,12-14,17-18,22-24,41H2,1-3H3/t26-,28?,29-,32-,33+,34+/m1/s1

SMILES Code

CC[C@H]([C@H](N)C(N(C([C@@H]1CC=CN1C([C@H](NC)CC2CCCC(C(c3nnccc3)=O)(C(c4nnccc4)=O)C2)=O)=O)[C@@H](C=O)CC5CCCCC5)=O)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 742.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Shimazoe T, Fukumoto T, Shuto T, Watanabe S. [Role of cholecystokinin receptor in methamphetamine-induced reverse tolerance]. Nihon Shinkei Seishin Yakurigaku Zasshi. 2002 Oct;22(5):207. Japanese. PubMed PMID: 12451697. 2: Pettibone DJ, Clineschmidt BV, Anderson PS, Freidinger RM, Lundell GF, Koupal LR, Schwartz CD, Williamson JM, Goetz MA, Hensens OD, et al. A structurally unique, potent, and selective oxytocin antagonist derived from Streptomyces silvensis. Endocrinology. 1989 Jul;125(1):217-22. PubMed PMID: 2544402.