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MedKoo Cat#: 591296 | Name: NGX-267 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NGX-267 is an M1 muscarinic agonist.

Chemical Structure

NGX-267 HCl
CAS#Unknown (HCl)

Theoretical Analysis

MedKoo Cat#: 591296

Name: NGX-267 HCl

CAS#: Unknown (HCl)

Chemical Formula: C10H19ClN2OS

Exact Mass: 214.1140

Molecular Weight: 250.78

Elemental Analysis: C, 47.89; H, 7.64; Cl, 14.14; N, 11.17; O, 6.38; S, 12.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
503431-81-0 (free base) 869377-75-3 (hydrate)
Synonym
NGX-267; NGX 267; NGX267; NGX-267 HCl; NGX-267 hydrochloride
IUPAC/Chemical Name
(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro[4.5]decan-3-one hydrochloride
InChi Key
BKGJDJVLUHDBNZ-QRPNPIFTSA-N
InChi Code
InChI=1S/C10H18N2OS.ClH/c1-3-8-9(13)11-10(14-8)4-6-12(2)7-5-10;/h8H,3-7H2,1-2H3,(H,11,13);1H/t8-;/m0./s1
SMILES Code
O=C1[C@H](CC)SC2(CCN(C)CC2)N1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 250.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Caccamo A, Oddo S, Billings LM, Green KN, Martinez-Coria H, Fisher A, LaFerla FM. M1 receptors play a central role in modulating AD-like pathology in transgenic mice. Neuron. 2006 Mar 2;49(5):671-82. PubMed PMID: 16504943. 2: Fisher A, Brandeis R, Bar-Ner RH, Kliger-Spatz M, Natan N, Sonego H, Marcovitch I, Pittel Z. AF150(S) and AF267B: M1 muscarinic agonists as innovative therapies for Alzheimer's disease. J Mol Neurosci. 2002 Aug-Oct;19(1-2):145-53. PubMed PMID: 12212772.