MedKoo Cat#: 529509 | Name: NGX-267
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NGX-267 is a muscarinic M1 agonist potentially for the treatment of Xerostomia, Alzheimer's disease and cognitive

Chemical Structure

NGX-267
CAS#503431-81-0 (free base)

Theoretical Analysis

MedKoo Cat#: 529509

Name: NGX-267

CAS#: 503431-81-0 (free base)

Chemical Formula: C10H18N2OS

Exact Mass: 214.1140

Molecular Weight: 214.32

Elemental Analysis: C, 56.04; H, 8.47; N, 13.07; O, 7.46; S, 14.96

Price and Availability

Size Price Availability Quantity
5mg USD 400.00
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Related CAS #
503431-81-0 (free base) 869377-75-3 (hydrate)
Synonym
NGX-267; AF-267B; NGX267; AF267B; NGX 267; AF 267B
IUPAC/Chemical Name
(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro[4.5]decan-3-one
InChi Key
PHOZOHFUXHPOCK-QMMMGPOBSA-N
InChi Code
InChI=1S/C10H18N2OS/c1-3-8-9(13)11-10(14-8)4-6-12(2)7-5-10/h8H,3-7H2,1-2H3,(H,11,13)/t8-/m0/s1
SMILES Code
O=C1[C@H](CC)SC2(CCN(C)CC2)N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 214.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Heinrich JN, Butera JA, Carrick T, Kramer A, Kowal D, Lock T, Marquis KL, Pausch MH, Popiolek M, Sun SC, Tseng E, Uveges AJ, Mayer SC. Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists. Eur J Pharmacol. 2009 Mar 1;605(1-3):53-6. doi: 10.1016/j.ejphar.2008.12.044. PubMed PMID: 19168056.