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MedKoo Cat#: 591284 | Name: trans-Cevimeline HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

trans-Cevimeline HCl, also known as AF 102A, is the trans-isomer of AF102B (Cevimeline). Cevimeline is a cholinergic analogue with glandular secretion stimulatory activity. Cevimeline binds to and activates muscarinic receptors, thereby increasing the secretions in exocrine salivary and sweat glands. This cholinergic agonist also increases the tone of smooth muscle in the gastrointestinal and urinary tracts. Cevimeline is being studied as a treatment for dry mouth caused by radiation therapy to the head and neck.

Chemical Structure

trans-Cevimeline HCl
trans-Cevimeline HCl
CAS#107220-29-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 591284

Name: trans-Cevimeline HCl

CAS#: 107220-29-1 (HCl)

Chemical Formula: C10H18lN

Exact Mass: 0.0000

Molecular Weight: 235.77

Elemental Analysis: C, 50.94; H, 7.70; Cl, 15.04; N, 5.94; O, 6.79; S, 13.60

Price and Availability

Related CAS #
107220-27-9 (free base) 107220-29-1 (HCl)
Synonym
AF 102A hydrochloride; AF 102A HCl; AF 102A; AF102A; AF-102A; trans-Cevimeline Hydrochloride; trans-Cevimeline HCl;
IUPAC/Chemical Name
(2R,2'R)-2'-methyl-4-azaspiro[bicyclo[2.2.2]octane-2,5'-[1,3]oxathiolane] hydrochloride
InChi Key
SURWTGAXEIEOGY-KXNXZCPBSA-N
InChi Code
InChI=1S/C10H17NOS.ClH/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11;/h8-9H,2-7H2,1H3;1H/t8-,10+;/m0./s1
SMILES Code
C[C@H](SC1)O[C@@]21CN3CCC2CC3.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 235.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Baharfar M, Yamini Y, Seidi S, Arain MB. A new approach for downscaling of electromembrane extraction as a lab on-a-chip device followed by sensitive Red-Green-Blue detection. Anal Chem. 2018 May 30. doi: 10.1021/acs.analchem.8b01224. [Epub ahead of print] PubMed PMID: 29847097. 2: Le Fur M, Molnár E, Beyler M, Fougère O, Esteban-Gómez D, Rousseaux O, Tripier R, Tircsó G, Platas-Iglesias C. Expanding the Family of Pyclen-Based Ligands Bearing Pendant Picolinate Arms for Lanthanide Complexation. Inorg Chem. 2018 May 30. doi: 10.1021/acs.inorgchem.8b00598. [Epub ahead of print] PubMed PMID: 29846067. 3: Mabrouk M, Beherei HH, ElShebiney S, Tanaka M. Newly developed controlled release subcutaneous formulation for tramadol hydrochloride. Saudi Pharm J. 2018 May;26(4):585-592. doi: 10.1016/j.jsps.2018.01.014. Epub 2018 Jan 31. PubMed PMID: 29844731; PubMed Central PMCID: PMC5961623. 4: Finocchio E, Gonzalez-Prior J, Gutierrez-Ortiz JI, Lopez-Fonseca R, Busca G, de Rivas B. Surface Characterization of Mesoporous CoO(x)/SBA-15 Catalyst upon 1,2-Dichloropropane Oxidation. Materials (Basel). 2018 May 29;11(6). pii: E912. doi: 10.3390/ma11060912. PubMed PMID: 29843475. 5: Bourgeois S, Bettoni C, Baron S, Wagner CA. Haploinsufficiency of the Mouse Atp6v1b1 Gene Leads to a Mild Acid-Base Disturbance with Implications for Kidney Stone Disease. Cell Physiol Biochem. 2018 May 25;47(3):1095-1107. doi: 10.1159/000490186. [Epub ahead of print] PubMed PMID: 29843146. 6: Bayat P, Lesage D, Cole RB. Low-energy collision induced dissociation (low-energy CID), collision induced dissociation (CID) and higher-energy collision dissociation (HCD) mass spectrometry for structural elucidation of saccharides and clarification of their dissolution mechanism in DMAc/LiCl. J Mass Spectrom. 2018 May 29. doi: 10.1002/jms.4205. [Epub ahead of print] PubMed PMID: 29813177. 7: Jiang XY, Zhang TQ, Li G, Gu YK, Gao F, Yao W, Zhang YY, Huang JH. Increasing radiofrequency ablation volumes with the use of internally cooled electrodes and injected hydrochloric acid in ex vivo bovine livers. Int J Hyperthermia. 2018 May 28:1-7. doi: 10.1080/02656736.2018.1472305. [Epub ahead of print] PubMed PMID: 29807444. 8: Anis SNS, Annuar MSM, Simarani K. Microbial biosynthesis and in vivo depolymerization of intracellular medium-chain-length poly-3-hydroxyalkanoates as potential route to platform chemicals. Biotechnol Appl Biochem. 2018 May 28. doi: 10.1002/bab.1666. [Epub ahead of print] PubMed PMID: 29806235. 9: Colodel C, Vriesmann LC, de Oliveira Petkowicz CL. Cell wall polysaccharides from Ponkan mandarin (Citrus reticulata Blanco cv. Ponkan) peel. Carbohydr Polym. 2018 Sep 1;195:120-127. doi: 10.1016/j.carbpol.2018.04.066. Epub 2018 Apr 21. PubMed PMID: 29804959. 10: Zhao L, Man Y, Liu S. Long non-coding RNA HULC promotes UVB-induced injury by up-regulation of BNIP3 in keratinocytes. Biomed Pharmacother. 2018 May 23;104:672-678. doi: 10.1016/j.biopha.2018.05.100. [Epub ahead of print] PubMed PMID: 29803927. 11: Ahmad N, Ahmad R, Alam MA, Ahmad FJ. Enhancement of oral bioavailability of doxorubicin through surface modified biodegradable polymeric nanoparticles. Chem Cent J. 2018 May 23;12(1):65. doi: 10.1186/s13065-018-0434-1. PubMed PMID: 29796830. 12: Ravandi F. MRD in HCL: does it matter? Blood. 2018 May 24;131(21):2277-2278. doi: 10.1182/blood-2018-04-843128. PubMed PMID: 29794075. 13: Foltin RW, Evans SM. Sex differences in the anorexigenic effects of dexfenfluramine and amphetamine in baboons. Exp Clin Psychopharmacol. 2018 May 24. doi: 10.1037/pha0000201. [Epub ahead of print] PubMed PMID: 29792471. 14: Charbit-Henrion F, Parlato M, Hanein S, Duclaux-Loras R, Nowak J, Begue B, Rakotobe S, Bruneau J, Fourrage C, Alibeu O, Rieux-Laucat F, Lévy E, Stolzenberg MC, Mazerolles F, Latour S, Lenoir C, Fischer A, Picard C, Aloi M, Amil Dias J, Ben Hariz M, Bourrier A, Breuer C, Breton A, Bronski J, Buderus S, Cananzi M, Coopman S, Crémilleux C, Dabadie A, Dumant-Forest C, Egritas Gurkan O, Fabre A, Fischer A, German Diaz M, Gonzalez-Lama Y, Goulet O, Guariso G, Gurcan N, Homan M, Hugot JP, Jeziorski E, Karanika E, Lachaux A, Lewindon P, Lima R, Magro F, Major J, Malamut G, Mas E, Mattyus I, Mearin LM, Melek J, Navas-Lopez VM, Paerregaard A, Pelatan C, Pigneur B, Pinto Pais I, Rebeuh J, Romano C, Siala N, Strisciuglio C, Tempia-Caliera M, Tounian P, Turner D, Urbonas V, Willot S, Ruemmele FM, Cerf-Bensussan N. Diagnostic Yield of Next-Generation Sequencing in Very Early-Onset Inflammatory Bowel Diseases: A Multicenter Study. J Crohns Colitis. 2018 May 18. doi: 10.1093/ecco-jcc/jjy068. [Epub ahead of print] PubMed PMID: 29788237. 15: André-Obadia N, Zyss J, Gavaret M, Lefaucheur JP, Azabou E, Boulogne S, Guérit JM, McGonigal A, Merle P, Mutschler V, Naccache L, Sabourdy C, Trébuchon A, Tyvaert L, Vercueil L, Rohaut B, Delval A. Recommendations for the use of electroencephalography and evoked potentials in comatose patients. Neurophysiol Clin. 2018 May 18. pii: S0987-7053(18)30034-0. doi: 10.1016/j.neucli.2018.05.038. [Epub ahead of print] Review. PubMed PMID: 29784540. 16: Terán-Baamonde J, Soto-Ferreiro RM, Carlosena A, Andrade JM, Prada D. Determination of cadmium in sediments by diluted HCI extraction and isotope dilution ICP-MS. Talanta. 2018 Aug 15;186:272-278. doi: 10.1016/j.talanta.2018.04.054. Epub 2018 Apr 21. PubMed PMID: 29784360. 17: Kim MU, Moon KW, Sohn JR, Byeon SH. Sensitivity Analysis of Weather Variables on Offsite Consequence Analysis Tools in South Korea and the United States. Int J Environ Res Public Health. 2018 May 18;15(5). pii: E1027. doi: 10.3390/ijerph15051027. PubMed PMID: 29783709. 18: Nielsen TS, Canibe N, Larsen FH. Butyrylation of Maize and Potato Starches and Characterization of the Products by Nuclear Magnetic Resonance and In Vitro Fermentation. Foods. 2018 May 18;7(5). pii: E79. doi: 10.3390/foods7050079. PubMed PMID: 29783633. 19: Mattes TA, Escalante-Semerena JC. Facile isolation of α-ribazole from vitamin B(12) hydrolysates using boronate affinity chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jul 15;1090:52-55. doi: 10.1016/j.jchromb.2018.05.022. Epub 2018 May 16. PubMed PMID: 29783174. 20: Rudnicki K, Poltorak L, Skrzypek S, Sudhölter EJR. Fused Silica Microcapillaries Used for a Simple Miniaturization of the Electrified Liquid-Liquid Interface. Anal Chem. 2018 May 30. doi: 10.1021/acs.analchem.8b01351. [Epub ahead of print] PubMed PMID: 29781599.