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MedKoo Cat#: 596447 | Name: Leucine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Leucine is an essential branched-chain amino acid important for hemoglobin formation.

Chemical Structure

Leucine
Leucine
CAS#61-90-5

Theoretical Analysis

MedKoo Cat#: 596447

Name: Leucine

CAS#: 61-90-5

Chemical Formula: C6H13NO2

Exact Mass: 131.0946

Molecular Weight: 131.18

Elemental Analysis: C, 54.94; H, 9.99; N, 10.68; O, 24.39

Price and Availability

Size Price Availability Quantity
100g USD 250.00
500g USD 550.00 2 Weeks
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Related CAS #
No Data
Synonym
Leucine; FEMA No. 3297; Leucinum; AI3-08899; NSC 46709; NSC-46709; NSC46709;
IUPAC/Chemical Name
L-leucine
InChi Key
ROHFNLRQFUQHCH-YFKPBYRVSA-N
InChi Code
InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
SMILES Code
CC(C)C[C@H](N)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
In vitro activity:
Mechanistically, Leucine increases the intracellular levels of hypoxia-inducible factor 1-α, a repressor of endocrine fate in the pancreas, by activating the mTOR complex 1 signaling pathway. Reference: Diabetes. 2012 Feb;61(2):409-17. https://pubmed.ncbi.nlm.nih.gov/22210321/
In vivo activity:
Stimulation of the TOR pathway with L-leucine rescued many developmental defects of ESCO2-mutant zebrafish embryos. Reference: PLoS Genet. 2013;9(10):e1003857. https://pubmed.ncbi.nlm.nih.gov/24098154/
Solvent mg/mL mM
Solubility
PBS (pH 7.2) 1.0 7.62
Water 6.7 50.81
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 131.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Sun M, Li S, Gong Q, Xiao Y, Peng F. Leucine Contributes to Copper Stress Tolerance in Peach (Prunus persica) Seedlings by Enhancing Photosynthesis and the Antioxidant Defense System. Antioxidants (Basel). 2022 Dec 13;11(12):2455. doi: 10.3390/antiox11122455. PMID: 36552663; PMCID: PMC9774504. 2. Rachdi L, Aïello V, Duvillié B, Scharfmann R. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17. doi: 10.2337/db11-0765. Epub 2011 Dec 30. PMID: 22210321; PMCID: PMC3266409. 3. Xu B, Lee KK, Zhang L, Gerton JL. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857. doi: 10.1371/journal.pgen.1003857. Epub 2013 Oct 3. PMID: 24098154; PMCID: PMC3789817. 4. Bruckbauer A, Zemel MB, Thorpe T, Akula MR, Stuckey AC, Osborne D, Martin EB, Kennel S, Wall JS. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77. doi: 10.1186/1743-7075-9-77. PMID: 22913271; PMCID: PMC3506499.
In vitro protocol:
1. Sun M, Li S, Gong Q, Xiao Y, Peng F. Leucine Contributes to Copper Stress Tolerance in Peach (Prunus persica) Seedlings by Enhancing Photosynthesis and the Antioxidant Defense System. Antioxidants (Basel). 2022 Dec 13;11(12):2455. doi: 10.3390/antiox11122455. PMID: 36552663; PMCID: PMC9774504. 2. Rachdi L, Aïello V, Duvillié B, Scharfmann R. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17. doi: 10.2337/db11-0765. Epub 2011 Dec 30. PMID: 22210321; PMCID: PMC3266409.
In vivo protocol:
1. Xu B, Lee KK, Zhang L, Gerton JL. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857. doi: 10.1371/journal.pgen.1003857. Epub 2013 Oct 3. PMID: 24098154; PMCID: PMC3789817. 2. Bruckbauer A, Zemel MB, Thorpe T, Akula MR, Stuckey AC, Osborne D, Martin EB, Kennel S, Wall JS. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77. doi: 10.1186/1743-7075-9-77. PMID: 22913271; PMCID: PMC3506499.
1: Puertollano R, Ferguson SM, Brugarolas J, Ballabio A. The complex relationship between TFEB transcription factor phosphorylation and subcellular localization. EMBO J. 2018 May 15. pii: e98804. doi: 10.15252/embj.201798804. [Epub ahead of print] Review. PubMed PMID: 29764979. 2: Holeček M. Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements. Nutr Metab (Lond). 2018 May 3;15:33. doi: 10.1186/s12986-018-0271-1. eCollection 2018. Review. PubMed PMID: 29755574; PubMed Central PMCID: PMC5934885. 3: Alfonso-Gonzalez C, Riesgo-Escovar JR. Fos metamorphoses: Lessons from mutants in model organisms. Mech Dev. 2018 May 14. pii: S0925-4773(18)30069-8. doi: 10.1016/j.mod.2018.05.006. [Epub ahead of print] Review. PubMed PMID: 29753813. 4: Nanson JD, Rahaman H, Ve T, Kobe B. Regulation of signaling by cooperative assembly formation in mammalian innate immunity signalosomes by molecular mimics. Semin Cell Dev Biol. 2018 May 5. pii: S1084-9521(17)30423-8. doi: 10.1016/j.semcdb.2018.05.002. [Epub ahead of print] Review. PubMed PMID: 29738879. 5: Gontijo AM, Garelli A. The biology and evolution of the Dilp8-Lgr3 pathway: A relaxin-like pathway coupling tissue growth and developmental timing control. Mech Dev. 2018 Apr 30. pii: S0925-4773(18)30072-8. doi: 10.1016/j.mod.2018.04.005. [Epub ahead of print] Review. PubMed PMID: 29715504. 6: Pinto A, Bonucci A, Maggi E, Corsi M, Businaro R. Anti-Oxidant and Anti-Inflammatory Activity of Ketogenic Diet: New Perspectives for Neuroprotection in Alzheimer's Disease. Antioxidants (Basel). 2018 Apr 28;7(5). pii: E63. doi: 10.3390/antiox7050063. Review. PubMed PMID: 29710809. 7: Sardi SP, Cedarbaum JM, Brundin P. Targeted therapies for Parkinson's disease: From genetics to the clinic. Mov Disord. 2018 Apr 27. doi: 10.1002/mds.27414. [Epub ahead of print] Review. PubMed PMID: 29704272. 8: Yu X, Li W, Deng Q, Li L, Hsi ED, Young KH, Zhang M, Li Y. MYD88 L265P Mutation in Lymphoid Malignancies. Cancer Res. 2018 May 15;78(10):2457-2462. doi: 10.1158/0008-5472.CAN-18-0215. Epub 2018 Apr 27. Review. PubMed PMID: 29703722. 9: Singh N, Ecker GF. Insights into the Structure, Function, and Ligand Discovery of the Large Neutral Amino Acid Transporter 1, LAT1. Int J Mol Sci. 2018 Apr 24;19(5). pii: E1278. doi: 10.3390/ijms19051278. Review. PubMed PMID: 29695141. 10: Pietrocola G, Arciola CR, Rindi S, Montanaro L, Speziale P. Streptococcus agalactiae Non-Pilus, Cell Wall-Anchored Proteins: Involvement in Colonization and Pathogenesis and Potential as Vaccine Candidates. Front Immunol. 2018 Apr 5;9:602. doi: 10.3389/fimmu.2018.00602. eCollection 2018. Review. PubMed PMID: 29686667; PubMed Central PMCID: PMC5900788. 11: Xiong Y, Yu J. Modeling Parkinson's Disease in Drosophila: What Have We Learned for Dominant Traits? Front Neurol. 2018 Apr 9;9:228. doi: 10.3389/fneur.2018.00228. eCollection 2018. Review. PubMed PMID: 29686647; PubMed Central PMCID: PMC5900015. 12: Shibuya K. Molecular aspects of flower senescence and strategies to improve flower longevity. Breed Sci. 2018 Jan;68(1):99-108. doi: 10.1270/jsbbs.17081. Epub 2018 Feb 27. Review. PubMed PMID: 29681752; PubMed Central PMCID: PMC5903976. 13: Lie E, Li Y, Kim R, Kim E. SALM/Lrfn Family Synaptic Adhesion Molecules. Front Mol Neurosci. 2018 Apr 5;11:105. doi: 10.3389/fnmol.2018.00105. eCollection 2018. Review. PubMed PMID: 29674953; PubMed Central PMCID: PMC5895706. 14: Khattab HM, Kubota S, Takigawa M, Kuboki T, Sebald W. The BMP-2 mutant L51P: a BMP receptor IA binding-deficient inhibitor of noggin. J Bone Miner Metab. 2018 Apr 17. doi: 10.1007/s00774-018-0925-0. [Epub ahead of print] Review. PubMed PMID: 29667005. 15: Schroeder A, de Wit J. Leucine-rich repeat-containing synaptic adhesion molecules as organizers of synaptic specificity and diversity. Exp Mol Med. 2018 Apr 9;50(4):10. doi: 10.1038/s12276-017-0023-8. Review. PubMed PMID: 29628503; PubMed Central PMCID: PMC5938020. 16: Trendeleva TA, Zvyagilskaya RA. Retrograde Signaling as a Mechanism of Yeast Adaptation to Unfavorable Factors. Biochemistry (Mosc). 2018 Feb;83(2):98-106. doi: 10.1134/S0006297918020025. Review. PubMed PMID: 29618296. 17: Chakraborty J, Jain A, Mukherjee D, Ghosh S, Das S. Functional diversification of structurally alike NLR proteins in plants. Plant Sci. 2018 Apr;269:85-93. doi: 10.1016/j.plantsci.2018.01.008. Epub 2018 Jan 31. Review. PubMed PMID: 29606220. 18: Waters EA, Shusta EV. The variable lymphocyte receptor as an antibody alternative. Curr Opin Biotechnol. 2018 Mar 26;52:74-79. doi: 10.1016/j.copbio.2018.02.016. [Epub ahead of print] Review. PubMed PMID: 29597074. 19: Wang X, Zhang H, Quinn PJ. Production of L-valine from metabolically engineered Corynebacterium glutamicum. Appl Microbiol Biotechnol. 2018 May;102(10):4319-4330. doi: 10.1007/s00253-018-8952-2. Epub 2018 Mar 29. Review. PubMed PMID: 29594358. 20: Inouye BM, Hughes FM Jr, Sexton SJ, Purves JT. The Emerging Role of Inflammasomes as Central Mediators in Inflammatory Bladder Pathology. Curr Urol. 2018 Feb;11(2):57-72. doi: 10.1159/000447196. Epub 2017 Dec 30. Review. PubMed PMID: 29593464; PubMed Central PMCID: PMC5836190.

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