Synonym
Ponceau 3R; NSC10461; NSC-10461; NSC10461
IUPAC/Chemical Name
2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-((2,4,5-trimethylphenyl)azo)-, disodium salt
InChi Key
SWPPXVFKWWEYSV-SERMZQFOSA-L
InChi Code
InChI=1S/C19H18N2O7S2.2Na/c1-10-6-12(3)16(7-11(10)2)20-21-18-15-5-4-14(29(23,24)25)8-13(15)9-17(19(18)22)30(26,27)28;;/h4-9,22H,1-3H3,(H,23,24,25)(H,26,27,28);;/q;2*+1/p-2/b21-20+;;
SMILES Code
O=S(C1=C(O)C(/N=N/C2=CC(C)=C(C)C=C2C)=C3C=CC(S(=O)([O-])=O)=CC3=C1)([O-])=O.[Na+].[Na+]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Ponceau 3R (C.I. 16155) is an azo dye that once was used as a red food colorant.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
0.00
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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7: Prival MJ, Bell SJ, Mitchell VD, Peiperl MD, Vaughan VL. Mutagenicity of benzidine and benzidine-congener dyes and selected monoazo dyes in a modified Salmonella assay. Mutat Res. 1984 Apr;136(1):33-47. PubMed PMID: 6371512.
8: Chung KT. The significance of azo-reduction in the mutagenesis and carcinogenesis of azo dyes. Mutat Res. 1983 Apr;114(3):269-81. Review. PubMed PMID: 6339890.
9: Brown JP, Dietrich PS. Mutagenicity of selected sulfonated azo dyes in the Salmonella/microsome assay: use of aerobic and anaerobic activation procedures. Mutat Res. 1983 Mar;116(3-4):305-15. PubMed PMID: 6339897.
10: Hartman CP, Andrews AW, Chung KT. Production of a mutagen from ponceau 3R by a human intestinal anaerobe. Infect Immun. 1979 Mar;23(3):686-9. PubMed PMID: 457255; PubMed Central PMCID: PMC414220.
11: Terada H, Maeda K, Funakoshi K, Kametani F. Binding of Ponceau 3R to bovine serum albumin. Chem Pharm Bull (Tokyo). 1971 Feb;19(2):335-62. PubMed PMID: 5549058.
12: Ogawa Y. [Basic studies on cellulose acetate electrophoretic technics. Ponceau 3R staining of beta and gamma globulin fractions in human serum]. Igaku To Seibutsugaku. 1966 Oct 10;73(4):169-72. Japanese. PubMed PMID: 4166983.
13: Ogawa Y, Miyauchi H. [Cellulose acetate electrophoresis technic. 4. Ponceau 3R staining of human serum globulin fractionation]. Igaku To Seibutsugaku. 1966 Sep 10;73(3):134-6. Japanese. PubMed PMID: 4166816.
14: Ogawa Y. [Cellulose acetate electrophoresis technic. 3. Ponceau 3R staining of human serum albumin on separax]. Igaku To Seibutsugaku. 1966 Sep 10;73(3):125-7. Japanese. PubMed PMID: 4166815.
15: Fujii S, Kamikura M, Oka N. [Standards of the National Institute of Hygienic Science for oil orange SS, naphthol yellow S, ponceau 3R]. Eisei Shikenjo Hokoku. 1965 Oct;83:72-4. Japanese. PubMed PMID: 5896414.
16: MANNELL WA. FURTHER INVESTIGATIONS ON PRODUCTION OF LIVER TUMOURS IN RATS BY PONCEAU 3R. Food Cosmet Toxicol. 1964 Jul;2:169-74. PubMed PMID: 14199201.
17: HANSEN WH, DAVIS KJ, FITZHUGH OG, NELSON AA. Chronic oral toxicity of Ponceau 3R. Toxicol Appl Pharmacol. 1963 Jan;5:105-18. PubMed PMID: 13952623.
18: GRICE HC, MANNELL WA, ALLMARK MG. Liver tumors in rats fed Ponceau 3R. Toxicol Appl Pharmacol. 1961 Sep;3:509-20. PubMed PMID: 13708546.
