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MedKoo Cat#: 526467 | Name: LEI-106

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LEI-106 is a novel potent sn-1 DAGLalpha inhibitor, blocking the hydrolysis of sn-1-oleoyl-2-AG, inhibiting the hydrolysis of 2-AG by the monoacylglycerol lipase ABHD6.

Chemical Structure

LEI-106
LEI-106
CAS#1620582-23-1

Theoretical Analysis

MedKoo Cat#: 526467

Name: LEI-106

CAS#: 1620582-23-1

Chemical Formula: C26H27NO6S

Exact Mass: 481.1600

Molecular Weight: 481.56

Elemental Analysis: C, 64.85; H, 5.65; N, 2.91; O, 19.93; S, 6.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LEI-106
IUPAC/Chemical Name
N-[(3,4-Dihydro-2,2-dimethyl-2H-1-benzopyran-6-yl)sulfonyl]-N-[(4-phenoxyphenyl)methyl]-glycine
InChi Key
FOEGBOXMDBPYEV-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H27NO6S/c1-26(2)15-14-20-16-23(12-13-24(20)33-26)34(30,31)27(18-25(28)29)17-19-8-10-22(11-9-19)32-21-6-4-3-5-7-21/h3-13,16H,14-15,17-18H2,1-2H3,(H,28,29)
SMILES Code
O=C(O)CN(S(=O)(C1=CC=C2C(CCC(C)(C)O2)=C1)=O)CC3=CC=C(OC4=CC=CC=C4)C=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 481.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Janssen FJ, Deng H, Baggelaar MP, Allarà M, van der Wel T, den Dulk H, Ligresti A, van Esbroeck AC, McGuire R, Di Marzo V, Overkleeft HS, van der Stelt M. Discovery of glycine sulfonamides as dual inhibitors of sn-1-diacylglycerol lipase α and α/β-hydrolase domain 6. J Med Chem. 2014 Aug 14;57(15):6610-22. doi: 10.1021/jm500681z. Epub 2014 Jul 23. PubMed PMID: 24988361.

View History

Monohexyl phosphate

Monohexyl phosphate