MedKoo Cat#: 596429 | Name: Dextramycine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dextramycine is an optic isomer of chloramphenicol which is not an antibiotic.

Chemical Structure

Dextramycine
Dextramycine
CAS#134-90-7

Theoretical Analysis

MedKoo Cat#: 596429

Name: Dextramycine

CAS#: 134-90-7

Chemical Formula: C11H12Cl2N2O5

Exact Mass: 322.0123

Molecular Weight: 323.12

Elemental Analysis: C, 40.89; H, 3.74; Cl, 21.94; N, 8.67; O, 24.76

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Synonym
Dextramycine; Dextramycin; Dextromycetin; (+)-Chloramphenicol; L-threo-Chloramphenicol; L-(+)-Threo-chloramphenicol; L-Chloramphenicol; (+)-Chloramphenicol;
IUPAC/Chemical Name
2,2-dichloro-N-((1S,2S)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl)acetamide
InChi Key
WIIZWVCIJKGZOK-IUCAKERBSA-N
InChi Code
InChI=1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m0/s1
SMILES Code
O=C(N[C@@H](CO)[C@@H](O)C1=CC=C([N+]([O-])=O)C=C1)C(Cl)Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 323.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shabad LM, Bogush TA, Konopleva IA, Belitsky GA. Dextramycine (the dextraisomer of chloramphenicol) as an inhibitor of the induction of lung adenomas in mice. Neoplasma. 1977;24:147-50. PMID: 865644. 2: Shabad LM, Belitsky GA, Bogush TA. Effect of chloramphenicol and dextramycine on the toxicity of carcinogenic hydrocarbons. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974;82(1):13-23. doi: 10.1007/BF00304380. PMID: 4280213. 3: Yanovych D, Berendsen B, Zasadna Z, Rydchuk M, Czymai T. A study of the origin of chloramphenicol isomers in honey. Drug Test Anal. 2018 Mar;10(3):416-422. doi: 10.1002/dta.2234. Epub 2017 Jul 27. PMID: 28643431. 4: Bogush TA, Konopleva IA. [Protective effect of chloramphenicol and dextramycin following the adrenocorticolytic action of 7, 12-dimethylbenz(a)anthracene]. Biull Eksp Biol Med. 1977 Mar;83(3):296-8. Russian. PMID: 403980.