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MedKoo Cat#: 591264 | Name: Montelukast
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Montelukast (trade name Singulair) is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.

Chemical Structure

Montelukast
Montelukast
CAS#158966-92-8 (free acid)

Theoretical Analysis

MedKoo Cat#: 591264

Name: Montelukast

CAS#: 158966-92-8 (free acid)

Chemical Formula: C35H36ClNO3S

Exact Mass: 585.2104

Molecular Weight: 585.19

Elemental Analysis: C, 71.72; H, 6.19; Cl, 6.05; N, 2.39; O, 8.19; S, 5.47

Price and Availability

Size Price Availability Quantity
50mg USD 350.00 2 Weeks
100mg USD 550.00 2 Weeks
200mg USD 950.00 2 Weeks
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Related CAS #
151767-02-1 (sodium) 158966-92-8 (free acid)
Synonym
Montelukast;
IUPAC/Chemical Name
Cyclopropaneacetic acid, 1-((((1R)-1-(3-((1E)-2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)-
InChi Key
UCHDWCPVSPXUMX-TZIWLTJVSA-N
InChi Code
InChI=1S/C35H36ClNO3S/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39)/b15-10+/t32-/m1/s1
SMILES Code
O=C(O)CC1(CS[C@@H](C2=CC=CC(/C=C/C3=NC4=CC(Cl)=CC=C4C=C3)=C2)CCC5=CC=CC=C5C(C)(O)C)CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 585.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bilgiç Mİ, Altun G, Çakıcı H, Gideroğlu K, Saka G. The protective effect of Montelukast against skeletal muscle ischemia reperfusion injury: An experimental rat model. Ulus Travma Acil Cerrahi Derg. 2018 May;24(3):185-190. doi: 10.5505/tjtes.2017.22208. PubMed PMID: 29786827. 2: Chin WK, Lee SWH. A systematic review on the off-label use of montelukast in atopic dermatitis treatment. Int J Clin Pharm. 2018 May 18. doi: 10.1007/s11096-018-0655-3. [Epub ahead of print] PubMed PMID: 29777328. 3: Akenroye AT, McEwan C, Saini SS. Montelukast Reduces Symptom Severity and Frequency in Patients with Angioedema-predominant Chronic Spontaneous Urticaria. J Allergy Clin Immunol Pract. 2018 May 4. pii: S2213-2198(18)30303-9. doi: 10.1016/j.jaip.2018.04.026. [Epub ahead of print] PubMed PMID: 29733981. 4: Dedaj R Dr, Unsel L Mrs. Case study: A Combination of Mepolizumab and Omaluzimab injections for severe asthma. J Asthma. 2018 May 7:1-3. doi: 10.1080/02770903.2018.1471706. [Epub ahead of print] PubMed PMID: 29733738. 5: Ghazanfar MN, Holm JG, Thomsen SF. Effectiveness of omalizumab in chronic spontaneous urticaria assessed with patient reported outcomes: a prospective study. J Eur Acad Dermatol Venereol. 2018 May 5. doi: 10.1111/jdv.15045. [Epub ahead of print] PubMed PMID: 29729103. 6: Piromkraipak P, Parakaw T, Phuagkhaopong S, Srihirun S, Chongthammakun S, Chaithirayanon K, Vivithanaporn P. Cysteinyl Leukotriene Receptor Antagonists Induce Apoptosis and Inhibit Proliferation of Human Glioblastoma Cells by Down-regulating B-cell Lymphoma 2 and Inducing Cell Cycle Arrest. Can J Physiol Pharmacol. 2018 May 4. doi: 10.1139/cjpp-2017-0757. [Epub ahead of print] PubMed PMID: 29726704. 7: Tang C, Lei H, Zhang J, Liu M, Jin J, Luo H, Xu H, Wu Y. Montelukast inhibits hypoxia inducible factor-1α translation in prostate cancer cells. Cancer Biol Ther. 2018 Apr 30:1-7. doi: 10.1080/15384047.2018.1451279. [Epub ahead of print] PubMed PMID: 29708817. 8: Chang AB, Oppenheimer JJ, Rubin BK, Weinberger M, Irwin RS; CHEST Expert Cough Panel. Chronic cough related to acute viral bronchiolitis in children - CHEST Expert Panel Report. Chest. 2018 Apr 25. pii: S0012-3692(18)30632-9. doi: 10.1016/j.chest.2018.04.019. [Epub ahead of print] PubMed PMID: 29704475. 9: Chen M, Zhou SY, Fabriaga E, Zhang PH, Zhou Q. Food-drug interactions precipitated by fruit juices other than grapefruit juice: An update review. J Food Drug Anal. 2018 Apr;26(2S):S61-S71. doi: 10.1016/j.jfda.2018.01.009. Epub 2018 Feb 15. Review. PubMed PMID: 29703387. 10: Karpov V, Ilarraza R, Catalli A, Kulka M. Cysteinyl leukotrienes C4 and D4 downregulate human mast cell expression of toll-like receptors 1 through 7. J Biol Regul Homeost Agents. 2018 Mar-Apr;32(2):233-239. PubMed PMID: 29685001. 11: Répásy B, Endrei D, Zemplényi A, Ágoston I, Boncz I. [The patients' cost of the montelukast therapy due to the generic substitution]. Orv Hetil. 2018 Apr;159(17):682-687. doi: 10.1556/650.2018.31020. Hungarian. PubMed PMID: 29681174. 12: Tokat AO, Akbulut A, Billur D, Koca G, Bayram P, Kuru S, Karasu S, Aydogmus S, Cakmak H, Ozmert S, Korkmaz M. Montelukast attenuates radioactive I131-induced pulmonary damage on rats. Int J Radiat Biol. 2018 Apr 27:1-9. doi: 10.1080/09553002.2018.1466065. [Epub ahead of print] PubMed PMID: 29659324. 13: Lu M, Wang M, Zhu X, Chen YH, Yao WZ. [Bronchial adenoid cystic carcinoma masquerading as bronchial asthma: a case report]. Beijing Da Xue Xue Bao Yi Xue Ban. 2018 Apr 18;50(2):378-380. Chinese. PubMed PMID: 29643544. 14: Ruttens D, Verleden SE, Demeyer H, Van Raemdonck DE, Yserbyt J, Dupont LJ, Vanaudenaerde BM, Vos R, Verleden GM. Montelukast for bronchiolitis obliterans syndrome after lung transplantation: A randomized controlled trial. PLoS One. 2018 Apr 6;13(4):e0193564. doi: 10.1371/journal.pone.0193564. eCollection 2018. PubMed PMID: 29624575; PubMed Central PMCID: PMC5889063. 15: Burman A. Question 2: Is there a role for Montelukast in the management of viral-induced wheeze in preschool children? Arch Dis Child. 2018 May;103(5):519-520. doi: 10.1136/archdischild-2018-314905. Epub 2018 Apr 4. PubMed PMID: 29618481. 16: Singh L, Virdi JK, Maslov LN, Singh N, Jaggi AS. Investigating the possible mechanisms involved in adenosine preconditioning-induced cardioprotection in rats. Cardiovasc Ther. 2018 Jun;36(3):e12328. doi: 10.1111/1755-5922.12328. Epub 2018 Apr 19. PubMed PMID: 29604187. 17: Wei J, Chen S, Guo W, Feng B, Yang S, Huang C, Chu J. Leukotriene D4 induces cellular senescence in osteoblasts. Int Immunopharmacol. 2018 May;58:154-159. doi: 10.1016/j.intimp.2017.12.027. Epub 2018 Mar 26. PubMed PMID: 29587204. 18: Suknuntha K, Yubolphan R, Krueaprasertkul K, Srihirun S, Sibmooh N, Vivithanaporn P. Leukotriene Receptor Antagonists Inhibit Mitogenic Activity in Triple Negative Breast Cancer Cells. Asian Pac J Cancer Prev. 2018 Mar 27;19(3):833-837. PubMed PMID: 29582642. 19: Helmy MW, Helmy MM, El-Mas MM. Enhanced lipoxygenase/LTD4 signaling accounts for the exaggerated hypertensive and nephrotoxic effects of cyclosporine plus indomethacin in rats. Biomed Pharmacother. 2018 Jun;102:309-316. doi: 10.1016/j.biopha.2018.03.065. Epub 2018 Mar 22. PubMed PMID: 29571015. 20: Maqsood U, Patel N. Extracorporeal membrane oxygenation (ECMO) for near-fatal asthma refractory to conventional ventilation. BMJ Case Rep. 2018 Mar 20;2018. pii: bcr-2017-223276. doi: 10.1136/bcr-2017-223276. PubMed PMID: 29559484.