L-Lactic acid | CAS#79-33-4 | substrate for lactic acid dehydrogenase and lactate oxidase

MedKoo Cat#: 596415 | Name: L-Lactic acid

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

L-Lactic acid is used as a substrate for lactic acid dehydrogenase and lactate oxidase.

Chemical Structure

L-Lactic acid

CAS#79-33-4

Theoretical Analysis

MedKoo Cat#: 596415

Name: L-Lactic acid

CAS#: 79-33-4

Chemical Formula: C3H6O3

Exact Mass: 90.0317

Molecular Weight: 90.08

Elemental Analysis: C, 40.00; H, 6.71; O, 53.28

Price and Availability

Size	Price	Availability	Quantity
10g	USD 450.00	2 Weeks

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Related CAS #

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Synonym

L-Lactic acid; Paralactic acid; L-(+)-Lactic acid; PH 90; Sarcolactic acid; Sarcolacticum acidum; Tisulac; BRN 1720251;

IUPAC/Chemical Name

(S)-2-hydroxypropanoic acid

InChi Key

JVTAAEKCZFNVCJ-REOHCLBHSA-N

InChi Code

InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m0/s1

SMILES Code

C[C@H](O)C(O)=O

Appearance

Liquid

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

L-Lactic acid is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid.

In vitro activity:

The DOX-loaded membranes were found to be cytotoxic to U-87 MG cells in vitro that decreased the cell viability from 82.92% to 25.49% from 24 to 72 h of co-incubation. In conclusion, this study has developed an effective approach to load DOX (doxorubicin) within a clinically approved poly (L-lactic acid)/gelatine membrane for local and long-term delivery of DOX for the treatment of glioblastoma. Reference: Regen Biomater. 2021 Jul 30;8(5):rbab043. https://pubmed.ncbi.nlm.nih.gov/34394954/

In vivo activity:

Poly (L-lactic acid) (PLLA) is commonly used in the bone tissue engineering field. This study designed a sequentially releasing PLLA scaffold including PLLA loaded with OTF (inner layer) and PLLA loaded with PNS (outer layer). This study assessed the osteogenic effect of angiogenesis in this scaffold by comparing it with the one-layered scaffold (PLLA embedded with OTF and PNS) in vivo in rabbits. Reference: J Funct Biomater. 2023 Jan 4;14(1):31. https://pubmed.ncbi.nlm.nih.gov/36662078/

	Solvent	mg/mL	mM
Solubility
	DMSO	100.0	1,110.15
	Water	100.0	1,110.15

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 90.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Liu B, Jin Z, Chen H, Liang L, Li Y, Wang G, Zhang J, Xu T. Electrospun poly (L-lactic acid)/gelatine membranes loaded with doxorubicin for effective suppression of glioblastoma cell growth in vitro and in vivo. Regen Biomater. 2021 Jul 30;8(5):rbab043. doi: 10.1093/rb/rbab043. PMID: 34394954; PMCID: PMC8358479. 2. Karava V, Siamidi A, Vlachou M, Christodoulou E, Bikiaris ND, Zamboulis A, Kostoglou M, Gounari E, Barmpalexis P. Poly(l-Lactic Acid)-co-poly(Butylene Adipate) New Block Copolymers for the Preparation of Drug-Loaded Long Acting Injectable Microparticles. Pharmaceutics. 2021 Jun 23;13(7):930. doi: 10.3390/pharmaceutics13070930. PMID: 34201567; PMCID: PMC8308927. 3. Feng G, Zhang P, Huang J, Yu Y, Yang F, Zhao X, Wang W, Li D, Sun S, Niu X, Chai L, Li J. Sequential Release of Panax Notoginseng Saponins and Osteopractic Total Flavone from Poly (L-Lactic Acid) Scaffold for Treating Glucocorticoid-Associated Osteonecrosis of Femoral Head. J Funct Biomater. 2023 Jan 4;14(1):31. doi: 10.3390/jfb14010031. PMID: 36662078; PMCID: PMC9863477. 4. Zhou J, Weng J, Huang X, Sun S, Yang Q, Lin H, Yang J, Guo H, Chi J. Repair effect of the poly (D,L-lactic acid) nanoparticle containing tauroursodeoxycholic acid-eluting stents on endothelial injury after stent implantation. Front Cardiovasc Med. 2022 Nov 8;9:1025558. doi: 10.3389/fcvm.2022.1025558. PMID: 36426231; PMCID: PMC9678935.

In vitro protocol:

In vivo protocol:

1. Feng G, Zhang P, Huang J, Yu Y, Yang F, Zhao X, Wang W, Li D, Sun S, Niu X, Chai L, Li J. Sequential Release of Panax Notoginseng Saponins and Osteopractic Total Flavone from Poly (L-Lactic Acid) Scaffold for Treating Glucocorticoid-Associated Osteonecrosis of Femoral Head. J Funct Biomater. 2023 Jan 4;14(1):31. doi: 10.3390/jfb14010031. PMID: 36662078; PMCID: PMC9863477. 2. Zhou J, Weng J, Huang X, Sun S, Yang Q, Lin H, Yang J, Guo H, Chi J. Repair effect of the poly (D,L-lactic acid) nanoparticle containing tauroursodeoxycholic acid-eluting stents on endothelial injury after stent implantation. Front Cardiovasc Med. 2022 Nov 8;9:1025558. doi: 10.3389/fcvm.2022.1025558. PMID: 36426231; PMCID: PMC9678935.

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