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MedKoo Cat#: 591225 | Name: Clopamide
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clopamide is a sulfamoylbenzamide piperidine. It is a thiazide-like diuretic which inhibits Secreted frizzled-related protein 4 and prevents diabetes mellitus.

Chemical Structure

Clopamide
Clopamide
CAS#636-54-4

Theoretical Analysis

MedKoo Cat#: 591225

Name: Clopamide

CAS#: 636-54-4

Chemical Formula: C14H20ClN3O3S

Exact Mass: 345.0914

Molecular Weight: 345.84

Elemental Analysis: C, 48.62; H, 5.83; Cl, 10.25; N, 12.15; O, 13.88; S, 9.27

Price and Availability

Size Price Availability Quantity
500mg USD 350.00 2 Weeks
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Related CAS #
No Data
Synonym
Brinaldix; Chlosudimeprimyl; Clopamide; Clopamidum; Adurix; Aquex; DT 327; DT327; DT-327;
IUPAC/Chemical Name
Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,6-dimethyl-1-piperidinyl)-, cis-
InChi Key
LBXHRAWDUMTPSE-AOOOYVTPSA-N
InChi Code
InChI=1S/C14H20ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(15)13(8-11)22(16,20)21/h6-10H,3-5H2,1-2H3,(H,17,19)(H2,16,20,21)/t9-,10+
SMILES Code
O=C(NN1[C@H](C)CCC[C@@H]1C)C2=CC=C(Cl)C(S(=O)(N)=O)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 345.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wise PH, Rihan Z, Dinwiddy G, Whichelow MJ, Butterfield WJ. Clopamide and carbohydrate metabolism. Med J Aust. 1969 Oct 18;2(16):795-8. doi: 10.5694/j.1326-5377.1969.tb107423.x. PMID: 5351496. 2: Gupta A, Zaheer MR, Iqbal S, Roohi, Ahmad A, Alshammari MB. Photodegradation and In Silico Molecular Docking Study of a Diuretic Drug: Clopamide. ACS Omega. 2022 Apr 13;7(16):13870-13877. doi: 10.1021/acsomega.2c00256. PMID: 35559154; PMCID: PMC9088902. 3: McNeil JJ, Conway EL, Drummer OH, Howes LG, Christophidis N, Louis WJ. Clopamide: plasma concentrations and diuretic effect in humans. Clin Pharmacol Ther. 1987 Sep;42(3):299-304. doi: 10.1038/clpt.1987.151. PMID: 3621784. 4: Effects of pindolol, or a pindolol/clopamide combination preparation, on plasma lipid levels in essential hypertension. Hunter Hypertension Research Group. Med J Aust. 1989 Jun 5;150(11):646, 648, 651-2. PMID: 2657348. 5: Johansson BW. Clopamide: a clinical study of a new oral diuretic. Angiology. 1968 Mar;19(3):161-8. doi: 10.1177/000331976801900304. PMID: 5644712. 6: du Preez MJ, Lockett CJ. Effect of clopamide, a thiazide diuretic, on copper and zinc levels in hypertensive patients. J Am Coll Nutr. 1991 Feb;10(1):34-7. doi: 10.1080/07315724.1991.10718123. PMID: 2010578. 7: Sharaf El-Din MM, Nassar MW, Attia KA, Demellawy MA, Kaddah MM. Validated liquid chromatography-tandem mass spectrometry method for simultaneous determination of clopamide, reserpine and dihydroergotoxine: Application to pharmacokinetics in human plasma. J Pharm Biomed Anal. 2016 Jun 5;125:236-44. doi: 10.1016/j.jpba.2016.03.051. Epub 2016 Mar 25. PMID: 27037980. 8: Nyberg G, Asplund J, Anagreus N, Aström B, Leppert J, Bergström R, Overmo J, Kullman S, Lessem J. New design for clinical trial of antihypertensive drugs applied to pindolol, clopamide, and combinations thereof. Lancet. 1982 Feb 13;1(8268):355-8. doi: 10.1016/s0140-6736(82)91390-3. PMID: 6120347. 9: Román O, Pino ME, Valenzuela A. Effects of pindolol and clopamide on blood lipids in arterial hypertensive patients. Cardiology. 1987;74(3):219-25. doi: 10.1159/000174200. PMID: 3594511. 10: Persson I. Treatment of hypertension in the elderly with pindolol and clopamide. J Am Geriatr Soc. 1978 Aug;26(8):337-40. doi: 10.1111/j.1532-5415.1978.tb03680.x. PMID: 670620. 11: Stüber W, Blume H, Sörgel F, Stenzhorn G. Gas-liquid chromatography-mass spectroscopy determination of clopamide in plasma. J Pharm Sci. 1989 Aug;78(8):679-82. doi: 10.1002/jps.2600780815. PMID: 2778674. 12: Imbs JL, Schmidt M, Parrenin A, Belhadj-Mostefa H, Schwartz J. Effets du clopamide et du furosémide sur l'urée sanguine du rat atteint de diabéte insipide congénital [Effect of clopamide and furosemide on blood urea in rats with congenital diabetes insipidus]. J Urol Nephrol (Paris). 1977 Apr- May;83(4-5):336-42. French. PMID: 894789. 13: Poli D, Maschio G, Broglio G, Borsatti A, Calzavara G. L'azione della clopamide sul bilancio idro-elettrolitico nel soggetto normale ed in infermi con edemi [Action of clopamide on the water-electrolyte balance in the normal subject and in patients with edema]. G Clin Med. 1965 Aug;46(8):654-69. Italian. PMID: 5863490. 14: Seedat YK, Rawat R. A dose-finding study of the combination of pindolol, clopamide and endralazine in the treatment of moderate-to-severe hypertension. S Afr Med J. 1984 Nov 3;66(18):682-4. PMID: 6387966. 15: Selchau M. Diuretika. 47 [Diuretics. 47]. Pharm Prax. 1970;9:193-9 concl. German. PMID: 4922055. 16: Tantbirojn P. A clinical trial of reserpine--clopamide--dihydroergocristine in the treatment of hypertension. J Med Assoc Thai. 1974 Nov;57(11):574-7. PMID: 4217815. 17: Clopamide (brinaldiz). Another oral diuretic. Drug Ther Bull. 1968 May 24;6(11):43-4. PMID: 5650011. 18: Hicks BH, Ward JD, Jarrett RJ, Keen H, Wise P. A controlled study of clopamide, clorexolone, and hydrochlorothiazide in diabetics. Metabolism. 1973 Feb;22(2):101-9. doi: 10.1016/0026-0495(73)90260-6. PMID: 4567002. 19: Odlind B, Lönnerholm G. Renal tubular secretion and effects of chlorothiazide, hydrochlorothiazide and clopamide: a study in the avian kidney. Acta Pharmacol Toxicol (Copenh). 1982 Sep;51(3):187-97. doi: 10.1111/j.1600-0773.1982.tb01013.x. PMID: 6814186. 20: Imbs JL, Desaulles E, Velly J, Bloch R, Schwartz J. Action du clopamide et de l'acide ethacrynique sur la sécrétion de rénine chez le chien [Effect of clopamide and ethacrynic acid on renin secretion in the dog]. Pflugers Arch. 1972;331(4):294-306. French. doi: 10.1007/BF00592690. PMID: 5064563.

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