Galangin | CAS#548-83-4 | TRPC5 inhibitor

MedKoo Cat#: 584446 | Name: Galangin

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Galangin inhibits Ca2+ entry into TRPC5 expressing cells and also induces autophagy.

Chemical Structure

Galangin

CAS#548-83-4

Theoretical Analysis

MedKoo Cat#: 584446

Name: Galangin

CAS#: 548-83-4

Chemical Formula: C15H10O5

Exact Mass: 270.0528

Molecular Weight: 270.24

Elemental Analysis: C, 66.67; H, 3.73; O, 29.60

Price and Availability

Size	Price	Availability
50mg	USD 250.00	2 Weeks
100mg	USD 450.00	2 Weeks
250mg	USD 850.00	2 Weeks

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Related CAS #

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Synonym

Galangin; Norizalpinin; 3,5,7-Trihydroxyflavone; Teptochrysin; NSC 407229; NSC407229; NSC-407229

IUPAC/Chemical Name

3,5,7-Trihydroxy-2-phenyl-4-benzopyrone

InChi Key

VCCRNZQBSJXYJD-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H

SMILES Code

O=C1C(O)=C(C2=CC=CC=C2)OC3=CC(O)=CC(O)=C13

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor. Galangin (Norizalpinin) also shows inhibition of CYP1A1 activity.

In vitro activity:

HG induced RAS activation, oxidative stress, while inhibited cell viability. Gal (galangin) suppressed oxidative stress-mediated apoptosis of HK-2 cells under the stimulation of HG via inhibiting RAS activation. Reference: Toxicol Res (Camb). 2021 May 17;10(3):551-560. https://pubmed.ncbi.nlm.nih.gov/34141169/

In vivo activity:

Iron overload model was established in male Wistar rats via intraperitoneal injection of 150 mg/kg iron-dextran subdivided over a ten-day experimental period. Galangin was administered in a daily oral dose of 15 mg/kg throughout the experimental period. Galangin significantly reduced liver iron content and serum ferritin level, and alleviated the iron-evoked oxidative stress. It enhanced the liver cell integrity as reflected by decreased serum activity of the liver enzymes. Mechanistically, galangin up-regulated the redox-regulating transcription factor Nrf2 and its responsive proteins HO-1 and NQO1. Interestingly, galangin up-regulated the antioxidant and anti-inflammatory protein PPARγ and serum hepcidin levels under the iron overload conditions. Reference: Life Sci. 2021 Jul 27;283:119856. https://pubmed.ncbi.nlm.nih.gov/34329667/

	Solvent	mg/mL	mM
Solubility
	DMSO	36.8	136.03
	DMF	30.0	111.01
	Ethanol	21.8	80.52
	Ethanol:PBS (pH 7.2) (1:3)	0.3	0.93

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 270.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Liao J, Liu B, Chen K, Hu S, Liu ZY, Li YX, Yang ZM, Zhang M, Chen X. Galangin attenuates oxidative stress-mediated apoptosis in high glucose-induced renal tubular epithelial cells through modulating renin-angiotensin system and PI3K/AKT/mTOR pathway. Toxicol Res (Camb). 2021 May 17;10(3):551-560. doi: 10.1093/toxres/tfab009. PMID: 34141169; PMCID: PMC8201591. 2. Li X, Jiang J, Yang Z, Jin S, Lu X, Qian Y. Galangin suppresses RANKL-induced osteoclastogenesis via inhibiting MAPK and NF-κB signalling pathways. J Cell Mol Med. 2021 Jun;25(11):4988-5000. doi: 10.1111/jcmm.16430. Epub 2021 May 3. PMID: 33939240; PMCID: PMC8178255. 3. Salama SA, Elshafey MM. Galangin mitigates iron overload-triggered liver injury: Up-regulation of PPARγ and Nrf2 signaling, and abrogation of the inflammatory responses. Life Sci. 2021 Jul 27;283:119856. doi: 10.1016/j.lfs.2021.119856. Epub ahead of print. PMID: 34329667. 4. Sangaraju R, Alavala S, Nalban N, Jerald MK, Sistla R. Galangin ameliorates Imiquimod-Induced psoriasis-like skin inflammation in BALB/c mice via down regulating NF-κB and activation of Nrf2 signaling pathways. Int Immunopharmacol. 2021 Jul;96:107754. doi: 10.1016/j.intimp.2021.107754. Epub 2021 May 24. PMID: 34162135.

In vitro protocol:

In vivo protocol:

1. Salama SA, Elshafey MM. Galangin mitigates iron overload-triggered liver injury: Up-regulation of PPARγ and Nrf2 signaling, and abrogation of the inflammatory responses. Life Sci. 2021 Jul 27;283:119856. doi: 10.1016/j.lfs.2021.119856. Epub ahead of print. PMID: 34329667. 2. Sangaraju R, Alavala S, Nalban N, Jerald MK, Sistla R. Galangin ameliorates Imiquimod-Induced psoriasis-like skin inflammation in BALB/c mice via down regulating NF-κB and activation of Nrf2 signaling pathways. Int Immunopharmacol. 2021 Jul;96:107754. doi: 10.1016/j.intimp.2021.107754. Epub 2021 May 24. PMID: 34162135.

Naylor et al (2016) Natural and synthetic flavonoid modulation of TRPC5 channels. Br.J.Pharmacol. 173 562 PMID: 26565375 Chen et al (2017) Galangin reduces the loss of dopaminergic neurons in an LPS-evoked model of Parkinson's disease in rats. Int.J.Mol.Sci. 19 PMID: 29267220 So et al (1996) Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutr.Cancer. 26 167 PMID: 8875554 Wen et al (2012) Galangin induces autophagy through upregulation of p53 in HepG2 cells. Pharmacology. 89 247 PMID: 22507894