MedKoo Cat#: 596389 | Name: Cysteamine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cysteamine is a medication intended for a number of indications, and approved by the FDA to treat cystinosis. It is stable aminothiol, i.e., an organic compound containing both an amine and a thiol functional groups. Cysteamine is a white, water-soluble solid. It is often used as salts of the ammonium derivative [HSCH2CH2NH3]+ including the hydrochloride, phosphocysteamine, and bitartrate.

Chemical Structure

Cysteamine
Cysteamine
CAS#60-23-1

Theoretical Analysis

MedKoo Cat#: 596389

Name: Cysteamine

CAS#: 60-23-1

Chemical Formula: C2H7NS

Exact Mass: 77.0299

Molecular Weight: 77.14

Elemental Analysis: C, 31.14; H, 9.15; N, 18.16; S, 41.56

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 Weeks
25g USD 450.00 2 Weeks
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Related CAS #
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Synonym
Cysteamine; Cystagon; Becaptan; 2-Aminoethanethiol; 2-Aminoethyl mercaptan; L 1573; L-1573; L1573; NSC 647528; NSC-647528; NSC647528;
IUPAC/Chemical Name
2-aminoethane-1-thiol; Cysteamine
InChi Key
UFULAYFCSOUIOV-UHFFFAOYSA-N
InChi Code
InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2
SMILES Code
NCCS
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2930.90.9135
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 77.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PubMed PMID: 29473717. 5: Makuloluwa AK, Shams F. Cysteamine hydrochloride eye drop solution for the treatment of corneal cystine crystal deposits in patients with cystinosis: an evidence-based review. Clin Ophthalmol. 2018 Jan 24;12:227-236. doi: 10.2147/OPTH.S133516. eCollection 2018. Review. PubMed PMID: 29416314; PubMed Central PMCID: PMC5789046. 6: Ariceta G, Giordano V, Santos F. Effects of long-term cysteamine treatment in patients with cystinosis. Pediatr Nephrol. 2017 Dec 19. doi: 10.1007/s00467-017-3856-4. [Epub ahead of print] Review. PubMed PMID: 29260317. 7: Nesterova G, Gahl WA. Cystinosis. 2001 Mar 22 [updated 2017 Dec 7]. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018. Available from http://www.ncbi.nlm.nih.gov/books/NBK1400/ PubMed PMID: 20301574. 8: Gawrieh S, Chalasani N. 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Review. PubMed PMID: 28771170; PubMed Central PMCID: PMC5618090. 12: Medic G, van der Weijden M, Karabis A, Hemels M. A systematic literature review of cysteamine bitartrate in the treatment of nephropathic cystinosis. Curr Med Res Opin. 2017 Nov;33(11):2065-2076. doi: 10.1080/03007995.2017.1354288. Epub 2017 Aug 3. Review. PubMed PMID: 28692321. 13: Gallego-Villar L, Hannibal L, Häberle J, Thöny B, Ben-Omran T, Nasrallah GK, Dewik AN, Kruger WD, Blom HJ. Cysteamine revisited: repair of arginine to cysteine mutations. J Inherit Metab Dis. 2017 Jul;40(4):555-567. doi: 10.1007/s10545-017-0060-4. Epub 2017 Jun 22. Review. PubMed PMID: 28643139; PubMed Central PMCID: PMC5740875. 14: Enns GM, Cowan TM. Glutathione as a Redox Biomarker in Mitochondrial Disease-Implications for Therapy. J Clin Med. 2017 May 3;6(5). pii: E50. doi: 10.3390/jcm6050050. Review. PubMed PMID: 28467362; PubMed Central PMCID: PMC5447941. 15: Mariani F, Roncucci L. Role of the Vanins-Myeloperoxidase Axis in Colorectal Carcinogenesis. Int J Mol Sci. 2017 Apr 27;18(5). pii: E918. doi: 10.3390/ijms18050918. Review. PubMed PMID: 28448444; PubMed Central PMCID: PMC5454831. 16: Sarkar B, Kulharia M, Mantha AK. Understanding human thiol dioxygenase enzymes: structure to function, and biology to pathology. Int J Exp Pathol. 2017 Apr;98(2):52-66. doi: 10.1111/iep.12222. Epub 2017 Apr 24. Review. PubMed PMID: 28439920; PubMed Central PMCID: PMC5485369. 17: Song M, Hwang H, Im CY, Kim SY. Recent Progress in the Development of Transglutaminase 2 (TGase2) Inhibitors. J Med Chem. 2017 Jan 26;60(2):554-567. doi: 10.1021/acs.jmedchem.6b01036. Epub 2016 Nov 21. Review. PubMed PMID: 28122456. 18: Veys KR, Elmonem MA, Arcolino FO, van den Heuvel L, Levtchenko E. Nephropathic cystinosis: an update. Curr Opin Pediatr. 2017 Apr;29(2):168-178. doi: 10.1097/MOP.0000000000000462. Review. PubMed PMID: 28107209. 19: Cherqui S, Courtoy PJ. 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