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MedKoo Cat#: 591205 | Name: Tripamide
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tripamide is a drug widely used in clinical practice for the treatment of hypertension and edema, which has been seen to lower both systolic and diastolic blood pressure in a clinical setting.

Chemical Structure

Tripamide
Tripamide
CAS#73803-48-2

Theoretical Analysis

MedKoo Cat#: 591205

Name: Tripamide

CAS#: 73803-48-2

Chemical Formula: C19H20ClN3O3S

Exact Mass: 369.0914

Molecular Weight: 369.86

Elemental Analysis: C, 51.96; H, 5.45; Cl, 9.58; N, 11.36; O, 12.98; S, 8.67

Price and Availability

Size Price Availability Quantity
25mg USD 400.00
100mg USD 1,100.00
250mg USD 1,850.00
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Related CAS #
No Data
Synonym
Tripamide;
IUPAC/Chemical Name
Benzamide, 3-(aminosulfonyl)-4-chloro-N-(octahydro-4,7-methano-2H-isoindol-2-yl)-, (3aalpha,4alpha,7alpha,7aalpha)-
InChi Key
UHLOVGKIEARANS-NIFPGPBJSA-N
InChi Code
InChI=1S/C16H20ClN3O3S/c17-14-4-3-11(6-15(14)24(18,22)23)16(21)19-20-7-12-9-1-2-10(5-9)13(12)8-20/h3-4,6,9-10,12-13H,1-2,5,7-8H2,(H,19,21)(H2,18,22,23)/t9-,10+,12-,13+
SMILES Code
O=C(NN1C[C@]2([H])[C@]3([H])CC[C@](C3)([H])[C@]2([H])C1)C4=CC=C(Cl)C(S(=O)(N)=O)=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 369.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li W, Li SG, Li L, Yang LJ, Li ZS, Li X, Ye AY, Xiong Y, Zhang Y, Xiong YY. Soyasaponin I alleviates hypertensive intracerebral hemorrhage by inhibiting the renin-angiotensin-aldosterone system. Clin Exp Hypertens. 2023 Dec 31;45(1):2177667. doi: 10.1080/10641963.2023.2177667. PMID: 36809885. 2: Kim Y, Hwang J, Kim M, Lee W. Determination of Tripamide in human urine by high-performance liquid chromatography and high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom. 2003;17(4):301-6. doi: 10.1002/rcm.913. PMID: 12569439. 3: Anand A, Anand A. Colorectal carcinoma: prognostic significance of gastrin. J Natl Cancer Inst. 1995 Jul 19;87(14):1086. doi: 10.1093/jnci/87.14.1086. PMID: 7616602. 4: Conrad KA, Fagan TC, Simons JA. The influence of hydrochlorothiazide and tripamide on serum and urinary amylase. J Clin Pharmacol. 1988 May;28(5):436-40. doi: 10.1002/j.1552-4604.1988.tb05756.x. PMID: 2455741. 5: Bope ET, Adams RC, Brewer SC, Cairns CB, Fosnaugh NR, Leidheiser PC Jr, Platt CW, Polsley JS, Romaker RR, Scarbrough SD, et al. Multicenter private practice comparison of tripamide and hydrochlorothiazide in the treatment of hypertension. Fam Pract Res J. 1988 Summer;7(4):197-204. PMID: 3075410. 6: Kishida H, Takiguchi F, Sugiki Y, Kuroki S, Tanaka T, Seino Y, Sasaki H, Fukuda J, Matsuo S. Hemodynamic characteristics of echocardiographic findings in hypertensive patients with negative U waves and effect of an antihypertensive drug, tripamide. Jpn Heart J. 1987 May;28(3):377-86. doi: 10.1536/ihj.28.377. PMID: 3626021. 7: Conrad KA, Fagan TC, Lee SM, Simons JA. Effect of tripamide on glucose tolerance in patients with hypertension. Clin Pharmacol Ther. 1986 Oct;40(4):476-9. doi: 10.1038/clpt.1986.209. PMID: 3530589. 8: Fagan TC, Conrad KA, Lee S, Mar JH, Simons J. Antihypertensive and biochemical dose-response study of tripamide. Clin Pharmacol Ther. 1986 Sep;40(3):352-8. doi: 10.1038/clpt.1986.187. PMID: 3527514. 9: Sasaki S, Lee LC, Nakamura Y, Iyota I, Okajima H, Takahashi H, Takeda K, Yoshimura M, Nakagawa M, Ijichi H. Antihypertensive and hypothalamic depressant effects of tripamide in spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1986 Sep-Oct;8(5):921-6. doi: 10.1097/00005344-198609000-00006. PMID: 2429091. 10: Nakai M, Matsui Y, Yamamoto J. Systemic and regional hemodynamic effects of E614 (tripamide) as studied in conscious SHR. Arch Int Pharmacodyn Ther. 1986 Feb;279(2):291-303. PMID: 3963940. 11: Kuramoto K, Masuyama Y. [Comparison of the clinical usefulness of diuretics in elderly and younger essential hypertension--double blind trial using tripamide]. Nihon Ronen Igakkai Zasshi. 1985 Jul;22(4):346-53. Japanese. doi: 10.3143/geriatrics.22.346. PMID: 3906202. 12: Yamada K, Yamato C, Sato T. Improved assay procedure for tripamide in blood. J Chromatogr. 1985 Apr 12;339(1):210-3. doi: 10.1016/s0378-4347(00)84646-0. PMID: 4019668. 13: Kawamura T, Nishi K. Effects of N-(4-azo-endo-tricyclo [5.2.1.0(2.6)]-decan-4-yl)-4-chloro-3-sulfamoylbenzamide (E 614; tripamide) on ganglionic transmission in the superior cervical ganglion of the guinea-pig. Arch Int Pharmacodyn Ther. 1984 Jun;269(2):187-200. PMID: 6089678. 14: Brater DC, Anderson S. Sites of action of tripamide. Clin Pharmacol Ther. 1983 Jul;34(1):79-85. doi: 10.1038/clpt.1983.133. PMID: 6861441. 15: Horie T, Ohno T, Kinoshita K. Studies on metabolism of tripamide. III. Metabolic fate of 14C-tripamide in rats and rabbits. Jpn J Pharmacol. 1982 Dec;32(6):1041-9. doi: 10.1254/jjp.32.1041. PMID: 7161960. 16: Horie T, Ohno T, Kinoshita K. Determination of tripamide and its metabolites in plasma, red blood cells and urine by high-performance liquid chromatography. J Chromatogr. 1982 Aug 13;231(1):111-9. doi: 10.1016/s0378-4347(00)80514-9. PMID: 7119053. 17: Asada H, Itoh T, Suzuki H, Ito Y, Kuriyama H. Effects of N-(4-azo-endo- tricyclo[5.2.1.0.(2.6)]-decan-4-yl)-4-chloro-3-sulfamoylbenzamide (E614; tripamide) on vascular smooth muscles. Gen Pharmacol. 1982;13(3):215-23. doi: 10.1016/0306-3623(82)90092-1. PMID: 7095400. 18: Horie T, Ohno T, Kinoshita K, Kitagawa H, Kitada M. Studies of metabolism of tripamide, a new antihypertensive agent. II. Metabolism by the hepatic microsomal enzymes. Xenobiotica. 1981 Oct;11(10):693-99. doi: 10.3109/00498258109049089. PMID: 7324501. 19: Horie T, Ohno T, Kinoshita K. Studies on the metabolism of tripamide, a new antihypertensive agent. I. Characterization of metabolites in rats. Xenobiotica. 1981 Mar;11(3):197-206. doi: 10.3109/00498258109045292. PMID: 7293216.