MedKoo Cat#: 464562 | Name: α-KGA sodium
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

α-Ketoglutaric acid is an α-keto acid and a rate-determining metabolic intermediate in the citric acid cycle in its conjugate base form, α-ketoglutarate. It is formed via oxidative decarboxylation of isocitrate by isocitrate dehydrogenase (IDH), oxidative deamination of glutamate by glutamate dehydrogenase, or by pyridoxal phosphate-dependent transamination. α-Ketoglutaric acid is decarboxylated to succinyl-CoA by α-ketoglutarate dehydrogenase, a rate limiting step in the citric acid cycle. It is a precursor of glutamine and glutamate, energy sources for enterocytes and various immune cells, and an antioxidant with roles in immune homeostasis, aging, protein synthesis, and bone development.

Chemical Structure

α-KGA sodium
α-KGA sodium
CAS#22202-68-2

Theoretical Analysis

MedKoo Cat#: 464562

Name: α-KGA sodium

CAS#: 22202-68-2

Chemical Formula: C5H6NaO5

Exact Mass: 0.0000

Molecular Weight: 169.09

Elemental Analysis: C, 35.52; H, 3.58; Na, 13.60; O, 47.31

Price and Availability

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5g USD 550.00 2 Weeks
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Synonym
α-KGA; αKGA; α KGA; 2-Oxoglutaric Acid; 2 Oxoglutaric Acid; α-Ketoglutaric Acid; α Ketoglutaric Acid; α-Ketoglutaric Acid sodium salt; α Ketoglutaric Acid sodium salt;
IUPAC/Chemical Name
2-oxopentanedioic acid, sodium salt
InChi Key
GPRYXSKURSLOCH-UHFFFAOYSA-N
InChi Code
InChI=1S/C5H6O5.Na/c6-3(5(9)10)1-2-4(7)8;/h1-2H2,(H,7,8)(H,9,10);
SMILES Code
O=C(O)C(CCC(O)=O)=O.[Na]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
DMSO 1.0 5.90
PBS (pH 7.2) 10.0 59.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 169.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang C, Ma J, Li Z, Liang Y, Xu Q, Xie X, Chen N. A strategy for L-isoleucine dioxygenase screening and 4-hydroxyisoleucine production by resting cells. Bioengineered. 2018 Jan 1;9(1):72-79. doi: 10.1080/21655979.2017.1304872. Epub 2017 Apr 28. Erratum in: Bioengineered. 2017 Nov 2;8(6):759. PMID: 28430004; PMCID: PMC5972919. 2: Nordgren A, Karlsson T, Wiklund L. Ammonium chloride and alpha-ketoglutaric acid increase glutamine availability in the early phase of induced acute metabolic acidosis. Acta Anaesthesiol Scand. 2006 Aug;50(7):840-7. doi: 10.1111/j.1399-6576.2006.01071.x. PMID: 16879467. 3: Wakayama M, Tsutsumi T, Yada H, Sakai K, Moriguchi M. Chemical modification of histidine residue of N-acyl-D-Glutamate amidohydrolase from Pseudomonas sp. 5f-1. Biosci Biotechnol Biochem. 1996 Apr;60(4):650-3. doi: 10.1271/bbb.60.650. PMID: 8829533. 4: Mitz SV, Giesy JP. Sewage effluent biomonitoring. II. Biochemical indicators of ammonia exposure in channel catfish. Ecotoxicol Environ Saf. 1985 Aug;10(1):40-52. doi: 10.1016/0147-6513(85)90005-3. PMID: 2863128. 5: Kretovich WL, Kariakina TI, Kazakova OV, Sidelnikova LI, Kaloshina GS, Shaposhnikov GL. Biosynthesis of amino acids from sucrose and Krebs cycle metabolites by Rhizobium lupini bacteroids. Mol Cell Biochem. 1983;51(1):61-6. doi: 10.1007/BF00215586. PMID: 6855750. 6: Mukherjee D, Laloraya MM. Keto acids and free amino acids during leaf growth in Bauhinia purpurea L. Experientia. 1977 Mar 15;33(3):304-5. doi: 10.1007/BF02002793. PMID: 858351.