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MedKoo Cat#: 562837 | Name: Ricinine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ricinine is an activator of the Wnt signaling pathway through casein kinase 1.

Chemical Structure

Ricinine
Ricinine
CAS#524-40-3

Theoretical Analysis

MedKoo Cat#: 562837

Name: Ricinine

CAS#: 524-40-3

Chemical Formula: C8H8N2O2

Exact Mass: 164.0586

Molecular Weight: 164.16

Elemental Analysis: C, 58.53; H, 4.91; N, 17.06; O, 19.49

Price and Availability

Size Price Availability Quantity
10mg USD 200.00 2 Weeks
50mg USD 450.00 2 Weeks
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Related CAS #
No Data
Synonym
Ricinine; Ricinin;
IUPAC/Chemical Name
4-Methoxy-1-methyl-2-oxopyridine-3-carbonitrile
InChi Key
PETSAYFQSGAEQY-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H8N2O2/c1-10-4-3-7(12-2)6(5-9)8(10)11/h3-4H,1-2H3
SMILES Code
N#CC1=C(OC)C=CN(C)C1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 164.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Sudebno- khimicheskoe i khimiko-toksikologicheskoe issledovanie metodom VEZhKh-MS/MS pri otravlenii ritsinom [Forensic chemical and chemicotoxicological examination of ricin poisoning by the HPLC-MS/MS method]. Sud Med Ekspert. 2023;66(3):34-39. Russian. doi: 10.17116/sudmed20236603134. PMID: 37192457. 5: Thiebot P, Maaziz N, Oppon C, Bertolo L, Magny R, Chevillard L, Mégarbane B, Houzé P, Labat L. Human plasma ricinine quantification by LC-HRMS after micro- solid-phase elution. Biomed Chromatogr. 2023 May;37(5):e5604. doi: 10.1002/bmc.5604. Epub 2023 Feb 27. PMID: 36776032. 6: Suthi S, Gopi D, Chaudhary A, Sarma PVGK. The Therapeutic Potential of 4-Methoxy-1-methyl-2-oxopyridine-3-carbamide (MMOXC) Derived from Ricinine on Macrophage Cell Lines Infected with Methicillin-Resistant Strains of Staphylococcus aureus. Appl Biochem Biotechnol. 2023 May;195(5):2843-2862. doi: 10.1007/s12010-022-04269-w. Epub 2022 Nov 23. PMID: 36418711. 7: Magdy G, ElNaggar MH, Belal F, Elmansi H. A novel quality-by-design optimized spectrofluorimetric method for the sensitive determination of ricinine alkaloid in edible oils. Food Chem. 2023 Mar 15;404(Pt A):134588. doi: 10.1016/j.foodchem.2022.134588. Epub 2022 Oct 20. PMID: 36272302. 8: Zheng KX, Liu CH, Wang S, Tzou YM, Chiang CM, Lin SR, Yang HY, Wu JJ, Chuang YH. Evaluating the release and metabolism of ricinine from castor cake fertilizer in soils using a LC-QTOF/MS coupled with SIRIUS workflow. Chemosphere. 2023 Jan;310:136865. doi: 10.1016/j.chemosphere.2022.136865. Epub 2022 Oct 14. PMID: 36244422. 9: Amoah K, Dong XH, Tan BP, Zhang S, Chi SY, Yang QH, Liu HY, Yan XB, Yang YZ, Zhang H. Ultra-Performance Liquid Chromatography-Mass Spectrometry-Based Untargeted Metabolomics Reveals the Key Potential Biomarkers for Castor Meal- Induced Enteritis in Juvenile Hybrid Grouper (Epinephelus fuscoguttatus♀ × E. lanceolatus♂). Front Nutr. 2022 Jun 16;9:847425. doi: 10.3389/fnut.2022.847425. PMID: 35811940; PMCID: PMC9261911. 10: Machado M, Queiroz CRR, Wilson TM, Sousa DER, Soto-Blanco B, Armién AG, Barros SS, Riet-Correa F, Castro MB. Neurological and gastrointestinal manifestations of spontaneous poisoning by Ricinus communis in goats. Toxicon. 2022 Jul 30;214:74-77. doi: 10.1016/j.toxicon.2022.05.004. Epub 2022 May 20. PMID: 35598632. 11: Nagu P, Sharma V, Behl T, Pathan AKA, Mehta V. Molecular Insights to the Wnt Signaling During Alzheimer's Disorder: a Potential Target for Therapeutic Interventions. J Mol Neurosci. 2022 Apr;72(4):679-690. doi: 10.1007/s12031-021-01940-5. Epub 2022 Jan 7. PMID: 34997460. 12: Zavala-Gómez CE, Rodríguez-deLeón E, Bah MM, Feregrino-Pérez AA, Campos- Guillén J, Amaro-Reyes A, Rodríguez-Morales JA, García-Trejo JF, Flores-Macias A, Figueroa-Brito R, Ramos-López MA. Effect of Salicylic Acid in the Yield of Ricinine in Ricinus communis under Greenhouse Condition. Plants (Basel). 2021 Sep 14;10(9):1902. doi: 10.3390/plants10091902. PMID: 34579435; PMCID: PMC8471134. 13: Hien DFDS, Paré PSL, Cooper A, Koama BK, Guissou E, Yaméogo KB, Yerbanga RS, Farrell IW, Ouédraogo JB, Gnankiné O, Ignell R, Cohuet A, Dabiré RK, Stevenson PC, Lefèvre T. Contrasting effects of the alkaloid ricinine on the capacity of Anopheles gambiae and Anopheles coluzzii to transmit Plasmodium falciparum. Parasit Vectors. 2021 Sep 15;14(1):479. doi: 10.1186/s13071-021-04992-z. PMID: 34526119; PMCID: PMC8444468. 14: Bambauer TP, Wagmann L, Weber AA, Meyer MR. Further development of a liquid chromatography-high-resolution mass spectrometry/mass spectrometry-based strategy for analyzing eight biomarkers in human urine indicating toxic mushroom or Ricinus communis ingestions. Drug Test Anal. 2021 Sep;13(9):1603-1613. doi: 10.1002/dta.3106. Epub 2021 Jun 10. PMID: 34080326. 15: Pham NKT, Tran TTL, Duong TH, Trung NT, Phan DCT, Mai DT, Nguyen VK, Huynh BLC, Nguyen TAT, Tran TD, Tran TNM, Nguyen TP. Ricicomin A, a new alkaloid from the leaves of Ricinus communis Linn. Nat Prod Res. 2022 Apr;36(8):1973-1979. doi: 10.1080/14786419.2020.1839456. Epub 2020 Oct 23. PMID: 33096957. 16: Lefever S, Geerts I, Vermeulen E, Vermeersch P, De Rydt F, Dobbels L, Gillis M, Croes K. Non-Lethal Intoxication by Ingestion of 50 Castor Beans: Serial Measurement of Ricinine in Blood, Plasma and Urine. J Anal Toxicol. 2021 May 14;45(5):e8-e12. doi: 10.1093/jat/bkaa139. PMID: 32991682. 17: Staňková M, Handlos P, Švidrnoch M, Maier V. Fatal intoxication by intravenous injection of castor bean (Ricinus communis L.) extract-a case study. Int J Legal Med. 2020 Nov;134(6):2133-2141. doi: 10.1007/s00414-020-02340-x. Epub 2020 Jun 17. PMID: 32548760. 18: Oriakhi K, Uadia PO, Shaheen F, Jahan H, Ibeji CU, Iqbal CM. Isolation, characterization, and hepatoprotective properties of betulinic acid and ricinine from Tetracarpidium conophorum seeds (Euphorbiaceae). J Food Biochem. 2021 Mar;45(3):e13288. doi: 10.1111/jfbc.13288. Epub 2020 Jun 11. PMID: 32529649. 19: Bucaretchi F, Borrasca-Fernandes CF, Prado CC, Lanaro R, Costa JL, Petroni OM, Giraldi T, Blotta MHSL, Justo-Junior AS, Sousa NL, Aragão FJL, De Capitani EM, Hyslop S. Near-fatal poisoning after ricin injection. Clin Toxicol (Phila). 2021 Feb;59(2):158-168. doi: 10.1080/15563650.2020.1771358. Epub 2020 Jun 1. PMID: 32475181. 20: Isenberg SL, Carter MD, Moon JL, Laughlin S, Petway M, Mojica MA, Rood JE, Gursky AK, Sheppard CI, Bagarozzi DA, Pirkle JL, Johnson RC. The Effects of Gamma Irradiation on Chemical Biomarker Recovery from Mixed Chemical/Biological Threat Exposure Specimens. J Appl Lab Med. 2020 Mar 1;5(2):273-280. doi: 10.1093/jalm/jfz022. PMID: 32445395; PMCID: PMC9022197.