VPC-14449 is a specific inhibitor of AR-DBD. It acts by inhibiting both Y594A and Q592A mutants, blocking the interaction of the AR with androgen response elements in the nucleus. Note: many vendors included Sigma mistakely listed 4-(4-(4,5-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine as VPC-14449. According to JBC paper (https://www.jbc.org/content/292/10/4359), the correct structure should be 4-(4-(2,4-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine.
MedKoo Cat#: 562834
Name: VPC-14449
CAS#: 1621375-32-3
Chemical Formula: C10H10Br2N4OS
Exact Mass: 391.8942
Molecular Weight: 394.08
Elemental Analysis: C, 30.48; H, 2.56; Br, 40.55; N, 14.22; O, 4.06; S, 8.14
The following data is based on the product molecular weight 394.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
