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MedKoo Cat#: 591195 | Name: Camylofin free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Camylofin is a smooth muscle relaxant with both anticholinergic action as well as direct smooth muscle action. Anticholinergic action is produced by inhibiting the binding of acetylcholine to muscarinic receptors, but the action is less pronounced. Direct smooth muscle relaxation is achieved by inhibiting phosphodiesterase type IV, which leads to increased cyclic AMP and eventually reduced cytosolic calcium.

Chemical Structure

Camylofin free base
Camylofin free base
CAS#54-30-8 (free base)

Theoretical Analysis

MedKoo Cat#: 591195

Name: Camylofin free base

CAS#: 54-30-8 (free base)

Chemical Formula: C19H32N2O2

Exact Mass: 320.2464

Molecular Weight: 320.48

Elemental Analysis: C, 71.21; H, 10.06; N, 8.74; O, 9.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
5892-41-1 (HCl) 54-30-8 (free base)
Synonym
Camylofin; Avadyl; Avocan; Navadyl; Novospasmin
IUPAC/Chemical Name
Glycine, N-(2-(diethylamino)ethyl)-2-phenyl-, isopentyl ester
InChi Key
RYOOHIUJEJZCFT-SFHVURJKSA-N
InChi Code
InChI=1S/C19H32N2O2/c1-5-21(6-2)14-13-20-18(17-10-8-7-9-11-17)19(22)23-15-12-16(3)4/h7-11,16,18,20H,5-6,12-15H2,1-4H3/t18-/m0/s1
SMILES Code
O=C(OCCC(C)C)[C@H](C1=CC=CC=C1)NCCN(CC)CC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 320.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sarbhjit K, S K B, Parmjit K, Surinder B. To compare the effect of camylofin dihydrochloride (anafortin) with combination of valethamate bromide (epidosin) and hyoscine butyl-N-bormide (buscopan) on cervical dilation. J Clin Diagn Res. 2013 Sep;7(9):1897-9. doi: 10.7860/JCDR/2013/6231.3345. Epub 2013 Jul 22. PubMed PMID: 24179892; PubMed Central PMCID: PMC3809631. 2: Rohwer AC, Khondowe O, Young T. Antispasmodics for labour. Cochrane Database Syst Rev. 2013 Jun 5;(6):CD009243. doi: 10.1002/14651858.CD009243.pub3. Review. PubMed PMID: 23737030. 3: Rohwer AC, Khondowe O, Young T. Antispasmodics for labour. Cochrane Database Syst Rev. 2012 Aug 15;(8):CD009243. doi: 10.1002/14651858.CD009243.pub2. Review. PubMed PMID: 22895986. 4: Dubey R, Dubey R, Omrey P, Vyas SP, Jain SK. Development and characterization of colon specific drug delivery system bearing 5-ASA and Camylofine dihydrochloride for the treatment of ulcerative colitis. J Drug Target. 2010 Sep;18(8):589-601. doi: 10.3109/10611860903572933. PubMed PMID: 20088681. 5: Elbarbry FA, Mabrouk MM, El-Dawy MA. Determination of the analgesic components of Spasmomigraine tablet by liquid chromatography with ultraviolet detection. J AOAC Int. 2007 Jan-Feb;90(1):94-101. PubMed PMID: 17373440. 6: Gupta C. Use of anafortan intravenous injection for treatment of colicky pain. J Indian Med Assoc. 2000 Aug;98(8):479, 482. PubMed PMID: 11294338. 7: Rosenkranz S, Deutsch HJ, Erdmann E. [33-year-old patient with postpartum myocardial infarct]. Internist (Berl). 1997 Jun;38(6):602-5. German. PubMed PMID: 9265005. 8: Machnig T, May A, Steininger H, von Streitberg U, Hahn EG, Ell C. [Ergotamine-induced rectal stenosis in a patient with long-term migraine]. Leber Magen Darm. 1993 Jul;23(4):166-8. German. PubMed PMID: 8366753. 9: Lee YH, Lee WC, Chen MT, Huang JK, Chung C, Chang LS. Acupuncture in the treatment of renal colic. J Urol. 1992 Jan;147(1):16-8. PubMed PMID: 1729516. 10: el-Sherif AE, Foda R, Norlen LJ, Yahia H. Treatment of renal colic by prostaglandin synthetase inhibitors and avafortan (analgesic antispasmodic). Br J Urol. 1990 Dec;66(6):602-5. PubMed PMID: 2265331. 11: Schvartsman S, Schvartsman C, Barsanti C. Camylofin intoxication reversed by naloxone. Lancet. 1988 Nov 26;2(8622):1246. PubMed PMID: 2903969. 12: Goldin J, Hayhurst M, Potgieter PD. Severe asthma due to intravenous avapyrazone and dipyrone. S Afr Med J. 1986 Feb 1;69(3):162. PubMed PMID: 3945867. 13: Fosseus CG, Straughan JL. Sudden death due to intravenous avapyrazone and dipyrone. S Afr Med J. 1983 Jul 16;64(3):81. PubMed PMID: 6867881. 14: Drees-Kulow ML. [Experiences with a migraine compound in medical practice. A multicenter study with Avamigran]. ZFA (Stuttgart). 1983 Feb 10;59(4):215-8. German. PubMed PMID: 6342291. 15: Crombez E, van den Bossche W, De Moerloose P. Gas-chromatographic determination of camylofine dihydrochloride in tablets and suppositories. J Chromatogr. 1976 Feb 4;117(1):161-6. PubMed PMID: 1249147. 16: Auclair JM, Anton JP, Bellocq J, Zylberberg B. [Study of the action of the association of glyceric ether of guaiacol and camylofine on the dilatation of the cervix during the labor]. Rev Fr Gynecol Obstet. 1970 Sep;65(9):523-8. French. PubMed PMID: 5466471. 17: SVIRCEVIC A, TEPAVCEVIC P, KOVAC T. [EXPERIENCES IN THE USE OF AVAFORTAN, A SPASMO-ANALGESIC AGENT]. Med Klin. 1965 Mar 12;60:422-3. German. PubMed PMID: 14260707. 18: REHSTEINER HP. [Comparative study on the labor-analgesic effect of Vendal and Centralgin-Avacan]. Ther Umsch. 1962 Aug;19:348-53. German. PubMed PMID: 14491125. 19: HASSELBACHER K. [Cystometric studies after administration of avacan]. Arztl Forsch. 1959 Feb 10;13(2):I/94-6. German. PubMed PMID: 13626684. 20: BLANZ H, SPORLEIN G. [Alleviation of labor pains with avafortan]. Munch Med Wochenschr. 1957 Dec 20;99(51):1950-5. German. PubMed PMID: 13504071.

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