Synonym
JTT-010; JTT 010; JTT010;
IUPAC/Chemical Name
(R)-3-(2-(aminomethyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-9-yl)-4-phenyl-1H-pyrrole-2,5-dione methanesulfonate
InChi Key
KRDZHKRBOOXUIR-BTQNPOSSSA-N
InChi Code
InChI=1S/C22H19N3O2.CH4O3S/c23-11-13-10-17-19(15-8-4-5-9-16(15)25(17)12-13)20-18(21(26)24-22(20)27)14-6-2-1-3-7-14;1-5(2,3)4/h1-9,13H,10-12,23H2,(H,24,26,27);1H3,(H,2,3,4)/t13-;/m1./s1
SMILES Code
O=C(C(C1=C(C[C@H](CN)C2)N2C3=C1C=CC=C3)=C4C5=CC=CC=C5)NC4=O.CS(=O)(O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
453.51
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Sasase T, Morinaga H, Abe T, Miyajima K, Ohta T, Shinohara M, Matsushita M, Kakehashi A. Protein kinase C beta inhibitor prevents diabetic peripheral neuropathy, but not histopathological abnormalities of retina in Spontaneously Diabetic Torii rat. Diabetes Obes Metab. 2009 Nov;11(11):1084-7. doi: 10.1111/j.1463-1326.2009.01082.x. Epub 2009 Jul 13. PubMed PMID: 19614949.
2: Tanaka M, Ubukata M, Matsuo T, Yasue K, Matsumoto K, Kajimoto Y, Ogo T, Inaba T. One-step synthesis of heteroaromatic-fused pyrrolidines via cyclopropane ring-opening reaction: application to the PKCbeta inhibitor JTT-010. Org Lett. 2007 Aug 16;9(17):3331-4. Epub 2007 Jul 26. PubMed PMID: 17655251.
3: Sasase T, Yamada H, Sakoda K, Imagawa N, Abe T, Ito M, Sagawa S, Tanaka M, Matsushita M. Novel protein kinase C-beta isoform selective inhibitor JTT-010 ameliorates both hyper- and hypoalgesia in streptozotocin- induced diabetic rats. Diabetes Obes Metab. 2005 Sep;7(5):586-94. PubMed PMID: 16050952.
