WEHI-539 has high affinity (IC50=1.1 nM) and selectivity for BCL-XL and potently kills cells by selectively antagonizing its prosurvival activity. It has more than a 400-fold higher affinity for BCL-XL versus other prosurvival BCL-2 family members.
MedKoo Cat#: 584438
Name: WEHI-539 HCl
CAS#: 2070018-33-4 (HCl)
Chemical Formula: C31H30ClN5O3S2
Exact Mass: 619.1479
Molecular Weight: 620.18
Elemental Analysis: C, 60.04; H, 4.88; Cl, 5.72; N, 11.29; O, 7.74; S, 10.34
The following data is based on the product molecular weight 620.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
