MedKoo Cat#: 596271 | Name: Jolkinolide A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Jolkinolide A is a diterpenoid extracted from the roots of Euphorbia fischeriana Steud.

Chemical Structure

Jolkinolide A
Jolkinolide A
CAS#37905-07-0

Theoretical Analysis

MedKoo Cat#: 596271

Name: Jolkinolide A

CAS#: 37905-07-0

Chemical Formula: C20H26O3

Exact Mass: 314.1882

Molecular Weight: 314.42

Elemental Analysis: C, 76.40; H, 8.34; O, 15.27

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Jolkinolide A;
IUPAC/Chemical Name
(1aS,3aR,7aS,7bS,11bR)-4,4,7a,11-tetramethyl-3,3a,4,5,6,7,7a,7b-octahydro-2H-oxireno[2',3':1,10a]phenanthro[3,2-b]furan-10(11bH)-one
InChi Key
OYXDHOVYZKWSRM-QDKUENGFSA-N
InChi Code
InChI=1S/C20H26O3/c1-11-15-12(22-17(11)21)10-14-19(4)8-5-7-18(2,3)13(19)6-9-20(14)16(15)23-20/h10,13-14,16H,5-9H2,1-4H3/t13-,14+,16-,19+,20+/m1/s1
SMILES Code
CC1=C2[C@@H](O3)[C@]3(CC[C@H]4[C@]5(C)CCCC4(C)C)[C@H]5C=C2OC1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 314.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cai D, Zhai W, Zhang Q, Liu J, Sun Y, Liu L, Liu J. Development of matrix solid-phase dispersion coupled with high-performance liquid chromatography for determination of jolkinolide A and jolkinolide B in Euphorbia fischeriana Steud. Nat Prod Res. 2017 Aug;31(15):1805-1811. doi: 10.1080/14786419.2017.1297993. Epub 2017 Mar 24. PubMed PMID: 28338342. 2: Shen L, Zhang SQ, Liu L, Sun Y, Wu YX, Xie LP, Liu JC. Jolkinolide A and Jolkinolide B Inhibit Proliferation of A549 Cells and Activity of Human Umbilical Vein Endothelial Cells. Med Sci Monit. 2017 Jan 14;23:223-237. PubMed PMID: 28087861; PubMed Central PMCID: PMC5256368. 3: Lai JZ, Zhang MH, Wu YC, Zhang DY, Wu XM, Hua WY. ent-Abietane Lactones from Euphorbia. Mini Rev Med Chem. 2017;17(4):380-397. Review. PubMed PMID: 27670580. 4: Wang Y, Xu X, Wang HB, Wu D, Li XO, Peng Q, Liu N, Sun WC. 17-Hydroxy-jolkinolide A inhibits osteoclast differentiation through suppressing the activation of NF-κB and MAPKs. Int Immunopharmacol. 2015 Dec;29(2):513-520. doi: 10.1016/j.intimp.2015.10.004. Epub 2015 Oct 9. PubMed PMID: 26456501. 5: Wang JL, Wang YQ, Li T, Wang H, Zhao M, Zhang SJ. [Study on the chemical constituents from fresh roots of Euphorbia fischeriana]. Zhong Yao Cai. 2010 Sep;33(9):1406-9. Chinese. PubMed PMID: 21243769. 6: Shi HM, Williams ID, Sung HH, Zhu HX, Ip NY, Min ZD. Cytotoxic diterpenoids from the roots of Euphorbia ebracteolata. Planta Med. 2005 Apr;71(4):349-54. PubMed PMID: 15856412. 7: Liu GF. [Isolation and identification of antitumor constituents of diterpenoids lactone in Euphorbia fischeriana Steud]. Zhong Yao Tong Bao. 1988 May;13(5):35-6, 63. Chinese. PubMed PMID: 3197209.