HW201877 is a Highly Potent and Orally Bioavailable Inhibitor of 15-Prostaglandin Dehydrogenase to Potentiate Tissue Repair and Regeneration. HW201877 demonstraties exceptional enzymatic inhibition (IC50 = 3.6 nM) and robust cellular efficacy in elevating PGE2 levels in A549 cells (4.8-fold increase vs control). Crucially, with favorable pharmacokinetic profiles, HW201877 demonstrated notable therapeutic efficacy in murine models of inflammatory bowel disease (IBD) and idiopathic pulmonary fibrosis (IPF).
MedKoo Cat#: 129086
Name: HW201877
CAS#: N/A
Chemical Formula: C23H26F2N6O2
Exact Mass: 456.2085
Molecular Weight: 456.50
Elemental Analysis: C, 60.52; H, 5.74; F, 8.32; N, 18.41; O, 7.01
The following data is based on the product molecular weight 456.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Li Q, Zang Y, An D, Yin S, Wu H, Wang M, Li C, Zhou Y, Liu L, Zhang X. Discovery of HW201877: A Highly Potent and Orally Bioavailable Inhibitor of 15-Prostaglandin Dehydrogenase to Potentiate Tissue Repair and Regeneration. J Med Chem. 2025 Jun 26. doi: 10.1021/acs.jmedchem.5c01361. Epub ahead of print. PMID: 40568827.
