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MedKoo Cat#: 562792 | Name: GK470

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GK470 is a inhibitor of group IVA cytosolic phospholipase A2 (GIVA cPLA2).

Chemical Structure

GK470
GK470
CAS#1621517-53-0

Theoretical Analysis

MedKoo Cat#: 562792

Name: GK470

CAS#: 1621517-53-0

Chemical Formula: C21H27NO4S

Exact Mass: 389.1661

Molecular Weight: 389.51

Elemental Analysis: C, 64.76; H, 6.99; N, 3.60; O, 16.43; S, 8.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GK470; GK-470; GK 470;
IUPAC/Chemical Name
Methyl 2-(2-(4-Octylphenoxy)acetyl)thiazole-4-carboxylate
InChi Key
OUBSYDDAZYCDGZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H27NO4S/c1-3-4-5-6-7-8-9-16-10-12-17(13-11-16)26-14-19(23)20-22-18(15-27-20)21(24)25-2/h10-13,15H,3-9,14H2,1-2H3
SMILES Code
O=C(C1=CSC(C(COC2=CC=C(CCCCCCCC)C=C2)=O)=N1)OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 389.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kokotos G, Feuerherm AJ, Barbayianni E, Shah I, Sæther M, Magrioti V, Nguyen T, Constantinou-Kokotou V, Dennis EA, Johansen B. Inhibition of group IVA cytosolic phospholipase A2 by thiazolyl ketones in vitro, ex vivo, and in vivo. J Med Chem. 2014 Sep 25;57(18):7523-35. doi: 10.1021/jm500192s. Epub 2014 Sep 3. PubMed PMID: 25152071.