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MedKoo Cat#: 562784 | Name: AL-438

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AL-438 is a non-steroidal selective modulator for the glucocorticoid receptor (GR).

Chemical Structure

AL-438
AL-438
CAS#239066-73-0

Theoretical Analysis

MedKoo Cat#: 562784

Name: AL-438

CAS#: 239066-73-0

Chemical Formula: C23H25NO2

Exact Mass: 347.1885

Molecular Weight: 347.45

Elemental Analysis: C, 79.51; H, 7.25; N, 4.03; O, 9.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AL-438; AL 438; AL438;
IUPAC/Chemical Name
10-Methoxy-2,2,4-trimethyl-5-prop-2-enyl-1,5-dihydrochromeno[3,4-f]quinoline
InChi Key
CZSDJYXNNJQXBB-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H25NO2/c1-6-8-18-22-15(21-17(25-5)9-7-10-19(21)26-18)11-12-16-20(22)14(2)13-23(3,4)24-16/h6-7,9-13,18,24H,1,8H2,2-5H3
SMILES Code
C=CCC(C1=C2C=CC3=C1C(C)=CC(C)(C)N3)OC4=C2C(OC)=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 347.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Reeves EK, Rayavarapu S, Damsker JM, Nagaraju K. Glucocorticoid analogues: potential therapeutic alternatives for treating inflammatory muscle diseases. Endocr Metab Immune Disord Drug Targets. 2012 Mar;12(1):95-103. Review. PubMed PMID: 22214335. 2: Chopra A. [(11)C]10-Methoxy-5-(2-propenyl)-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3, 4-f]quinoline. 2009 Jan 13 [updated 2009 Apr 6]. Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. Available from http://www.ncbi.nlm.nih.gov/books/NBK22972/ PubMed PMID: 20641180. 3: De Bosscher K, Beck IM, Haegeman G. Classic glucocorticoids versus non-steroidal glucocorticoid receptor modulators: survival of the fittest regulator of the immune system? Brain Behav Immun. 2010 Oct;24(7):1035-42. doi: 10.1016/j.bbi.2010.06.010. Epub 2010 Jun 25. Review. PubMed PMID: 20600811. 4: Xu Y, Zhang T, Chen M. Combining 3D-QSAR, docking, molecular dynamics and MM/PBSA methods to predict binding modes for nonsteroidal selective modulator to glucocorticoid receptor. Bioorg Med Chem Lett. 2009 Jan 15;19(2):393-6. doi: 10.1016/j.bmcl.2008.11.069. Epub 2008 Nov 24. PubMed PMID: 19081253. 5: Wuest F, Kniess T, Bergmann R, Henry B, Pietzsch J. Synthesis and radiopharmacological characterization of [11C]AL-438 as a nonsteroidal ligand for imaging brain glucocorticoid receptors. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4035-9. Epub 2007 Apr 29. PubMed PMID: 17499506. 6: Owen HC, Miner JN, Ahmed SF, Farquharson C. The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438. Mol Cell Endocrinol. 2007 Jan 29;264(1-2):164-70. Epub 2006 Dec 19. PubMed PMID: 17182172. 7: Rosen J, Miner JN. The search for safer glucocorticoid receptor ligands. Endocr Rev. 2005 May;26(3):452-64. Epub 2005 Apr 6. Review. PubMed PMID: 15814846. 8: Doggrell S. Is AL-438 likely to have fewer side effects than the glucocorticoids? Expert Opin Investig Drugs. 2003 Jul;12(7):1227-9. PubMed PMID: 12831356. 9: Coghlan MJ, Jacobson PB, Lane B, Nakane M, Lin CW, Elmore SW, Kym PR, Luly JR, Carter GW, Turner R, Tyree CM, Hu J, Elgort M, Rosen J, Miner JN. A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects. Mol Endocrinol. 2003 May;17(5):860-9. Epub 2003 Feb 13. PubMed PMID: 12586843. 10: Elmore SW, Coghlan MJ, Anderson DD, Pratt JK, Green BE, Wang AX, Stashko MA, Lin CW, Tyree CM, Miner JN, Jacobson PB, Wilcox DM, Lane BC. Nonsteroidal selective glucocorticoid modulators: the effect of C-5 alkyl substitution on the transcriptional activation/repression profile of 2,5-dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines. J Med Chem. 2001 Dec 6;44(25):4481-91. PubMed PMID: 11728194.