MedKoo Cat#: 534999 | Name: Difenoximide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Difenoximide is a water insoluble derivative of diphenoxylate, a chemical congener of meperidine. Difenoximide has been shown to have a greater ability than methadone to suppress opiate withdrawal in addicted mice and it has produced less physical dependence than morphine and methadone in laboratory animals.

Chemical Structure

Difenoximide
CAS#47806-92-8

Theoretical Analysis

MedKoo Cat#: 534999

Name: Difenoximide

CAS#: 47806-92-8

Chemical Formula: C32H31N3O4

Exact Mass: 521.2315

Molecular Weight: 521.62

Elemental Analysis: C, 73.68; H, 5.99; N, 8.06; O, 12.27

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Difenoximide
IUPAC/Chemical Name
1-Piperidinebutanenitrile, 4-(((2,5-dioxo-1-pyrrolidinyl)oxy)carbonyl)-alpha,alpha,4-triphenyl-
InChi Key
FTOLAXZXUUHQQX-UHFFFAOYSA-N
InChi Code
InChI=1S/C32H31N3O4/c33-24-32(26-12-6-2-7-13-26,27-14-8-3-9-15-27)20-23-34-21-18-31(19-22-34,25-10-4-1-5-11-25)30(38)39-35-28(36)16-17-29(35)37/h1-15H,16-23H2
SMILES Code
N#CC(C1=CC=CC=C1)(C2=CC=CC=C2)CCN3CCC(C4=CC=CC=C4)(C(ON5C(CCC5=O)=O)=O)CC3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 521.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tennant FS Jr, Krantz KD, Dobrin EI. Use of difenoximide (SC-26100) for narcotic detoxification: a preliminary tolerance and efficacy study. Am J Drug Alcohol Abuse. 1977;4(1):123-35. doi: 10.3109/00952997709002753. PMID: 612187.