MedKoo Cat#: 596164 | Name: Jaspisamide A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Jaspisamide A is an actin-binding protein.

Chemical Structure

Jaspisamide A
Jaspisamide A
CAS#149420-76-8

Theoretical Analysis

MedKoo Cat#: 596164

Name: Jaspisamide A

CAS#: 149420-76-8

Chemical Formula: C45H62N4O12

Exact Mass: 850.4364

Molecular Weight: 851.00

Elemental Analysis: C, 63.51; H, 7.34; N, 6.58; O, 22.56

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Jaspisamide A;
IUPAC/Chemical Name
N-((E)-11-((12Z,22Z,32Z,4Z,15E)-13-hydroxy-19-methoxy-8,18-dimethyl-11,17-dioxo-10-oxa-1(2,4),2,3(4,2)-trioxazolacyclononadecaphane-4,15-dien-9-yl)-4,10-dimethoxy-3,5,9-trimethyl-6-oxoundec-1-en-1-yl)-N-methylformamide
InChi Key
XGTLKZLKDQCQIQ-AMFGEKGLSA-N
InChi Code
InChI=1S/C45H62N4O12/c1-27-13-10-11-16-40-46-34(24-58-40)44-48-35(25-60-44)45-47-33(23-59-45)43(57-9)31(5)36(52)15-12-14-32(51)21-41(54)61-39(27)22-38(55-7)28(2)17-18-37(53)30(4)42(56-8)29(3)19-20-49(6)26-50/h11-12,15-16,19-20,23-32,38-39,42-43,51H,10,13-14,17-18,21-22H2,1-9H3/b15-12+,16-11-,20-19+
SMILES Code
CC1CC/C=C\C2=NC(C3=NC(C4=NC(C(OC)C(C)C(/C=C/CC(O)CC(OC1CC(OC)C(CCC(C(C(OC)C(/C=C/N(C=O)C)C)C)=O)C)=O)=O)=CO4)=CO3)=CO2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 851.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tanaka J, Yan Y, Choi J, Bai J, Klenchin VA, Rayment I, Marriott G. Biomolecular mimicry in the actin cytoskeleton: mechanisms underlying the cytotoxicity of kabiramide C and related macrolides. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13851-6. Epub 2003 Nov 11. PubMed PMID: 14612571; PubMed Central PMCID: PMC283510. 2: Klenchin VA, Allingham JS, King R, Tanaka J, Marriott G, Rayment I. Trisoxazole macrolide toxins mimic the binding of actin-capping proteins to actin. Nat Struct Biol. 2003 Dec;10(12):1058-63. Epub 2003 Oct 26. PubMed PMID: 14578936. 3: Kobayashi J, Murata O, Shigemori H. Jaspisamides A-C, new cytotoxic macrolides from the Okinawan sponge Jaspis sp. J Nat Prod. 1993 May;56(5):787-91. PubMed PMID: 8326327.